The incidence of malignant tumors in the primary immunodeficiency diseases is dramatically increased. Four patients with primary immunodeficiencies who developed fatal malignancies are reported. Lymphoreticular tumors and leukemia predominate in most conditions, but epithelial neoplasms are the most common tumors in selective Iga deficiency, and they comprise over one-fourth of malignancies in ...

neutropenia is characterized by decrease in the absolute number of circulating neutrophils and an increase susceptibility to infections. the current study was performed in order to explain the clinical and laboratory findings of patients with antibody deficiency disorders associated neutropenia. the patients' records of 19 neutropenic cases out of 207 patients with antibody deficiencies, who ha...

Evans syndrome, a combination of autoimmune hemolytic anemia and immune thrombocytopenia, is rare disease in children. In childhood, it may turn out to be one the first manifestations primary immunodeficiency or an dysregulation syndrome. Here we present clinical case patient who was initially diagnosed with syndrome did not respond well therapy. Based on results genetic testing, child then imm...

Although primary immunodeficiency disorders are relatively rare, intensive investigation of these disorders has yielded a great wealth of understanding of basic immunologic mechanisms in host defense, inflammation, and autoimmunity. These advances have led to important developments for the treatment not only of the primary immunodeficiencies but also for patients with secondary immunocompromise...

primary non-hodgkin lymphoma of liver is a very rare malignancy. here we report a case of primary hepatic burkitt’s lymphoma in a 34-year old man who was known case of acquired immunodeficiency syndrome (aids) and presented with weight loss, abdominal pain, and fever. positive laboratory findings were mild anemia and elevated levels of lactate dehydrogenase (ldh) and alkaline phosphatase (alp)....

in recent years, tuberculosis has had a significant rise, caused mainly by the epidemic of acquired immunodeficiency syndrome. the anorectal tuberculosis is a very rare presentation. herein, we presented a 67-year-old man who has had renal transplantation and presented with hematochezia and painful defecation since 6 months before. biopsy was taken from the lower rectal ulcerated lesion. histop...

Skin fibroblasts were cultured from 15 patients with primary immunodeficiency diseases associated with a high cancer risk, including sex-linked agammaglobulinemia, IgA deficiency, variable immunodeficiency, ataxia-telangiectasia (cerebellar malfunction and abnormalities of blood vessels and immune response), Wiskott-Aldrich syndrome (low platelet count, eczema, and abnormal immune mechanism), a...