Cleavage and polyadenylation is an essential processing reaction required for the maturation of pre-mRNAs into stable, export- and translation-competent mature mRNA molecules. This reaction requires the assembly of a multimeric protein complex onto a bipartite core sequence element consisting of an AAUAAA hexamer and a GU/U-rich downstream sequence element. In this study we have analyzed 3' end...

The cutting is an important machining technology, in which is belong to nonlinear large deformation, involving material nonlinear, geometry nonlinear and original bug, the thermal energy coupling question, and the nonlinear boundary condition, and so on. For the processing of metal cutting, using the large-scale commercial finite element theory, the coupling finite element model is established ...

Execution Model SIGMA-1 is a dynamic dataflow machine having ability of vector processing in control flow manner. SIGMA-1 uses structure-flow processing scheme for handling data structures in dataflow architecture. In this scheme, the arrival of a data structure unrolls the control structure which processes the data structure itself using a high-level structure. A structure-flow is defined as a...

at the beginning of the present century, problems such as education of mentally retarded children, classification and placement of job applicants in industrial and military organizations, and students selection, gave impetus to the development of intelligence tests and the formulation of theories of intelligence. for many years factorial theories of intelligence dominated the field, but piaget&...

We have previously identified a G-rich sequence (GRS) as an auxiliary downstream element (AUX DSE) which influences the processing efficiency of the SV40 late polyadenylation signal. We have now determined that sequences downstream of the core U-rich element (URE) form a fundamental part of mammalian polyadenylation signals. These novel AUX DSEs all influenced the efficiency of 3'-end processin...