Newborns are at increased risk of jaundice, a condition in which excess bilirubin accumulates in blood. Left untreated, jaundice can lead to neurological impairment and death. Jaundice resulting from unconjugated hyperbilirubinemia is easily treated with exposure to blue light, and phototherapy systems have been developed for low-resource settings; however, there are no appropriate solutions to...

BACKGROUND AND AIMS Several conditions that delay gastrointestinal transit are associated with unconjugated hyperbilirubinaemia. We hypothesised that the gastrointestinal transit time is directly related to plasma unconjugated bilirubin (UCB) concentrations, and that this relationship can be used to develop a new therapeutic strategy for severe unconjugated hyperbilirubinaemia in the Gunn rat m...

Phototherapy is generally considered a very safe and well-tolerated treatment for hyperbilirubinaemia. However, clinical users should be aware of the unwanted effects of using phototherapy. Affection of neonatal immune system due to phototherapy has been reported. This study aimed to evaluate the effect of phototherapy on level of CD4+, CD8+ and natural killer (NK) (CD16+ & CD65+) lymphocytes s...

Phototherapy: A simple and safe treatment for Neonatal Jaundice. Jaundice is a common finding in premature and full term newborns. Phototherapy has been widely used in the management of Neonatal unconjugated Hyperbilirubinemia for over five decades. Phototherapy devices include Fluorescent, Halogen, Fiberoptic or Light-Emitting Diode light sources. Safety issues and possible complications of ph...

One of the causes of neonatal hyperbilirubinemia is increased reabsorption of bilirubin from meconium in the gastrointestinal tract. This occurs when the conjugated bilirubin which is excreted into the colon is 'unconjugated by beta glucuronidase activity, present in the neonatal intestine, which hydrolyzes bilirubin diglucuronide into unconjugated bilirubin, which subsequently is reabsorbe...

We report the first case of acute cholecystitis due to indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus who had been receiving indinavir for 56 months. Infrared spectroscopy demonstrated that the gallstone was composed of indinavir monohydrate (50%), calcium bilirubinate (28%), calcium palmitate (10%), cholesterol (7%), and proteins (5%). The role of high...

Introduction/Objective. Gilbert syndrome (GS) is the most common hereditary hyperbilirubinemia. As well as mild unconjugated hyperbilirubinemia, it characterized by excess of bilirubin monoglucuronide over diglucuronide in bile and thus increases risk biliary calculosis. The aim study was to determine importance GS a factor development cholelithiasis children. Methods. included sample 31 childr...

Introduction: One of the old treatment methods for unconjugated hyperbilirubinemia in neonates is blood exchange transfusion, which expensive, possibly high-risk, and time-consuming. Today phototherapy as a novel method can be good alternative. Objectives: This study aimed to evaluate zinc level alternation after with hyperbilirubinemia. Patients Methods: A descriptive-analytical was conducted ...