AIMS To compare the therapeutic efficacy of placebo, propranolol, and fluoxetine in patients with vasovagal syncope (VVS). METHODS AND RESULTS Ninety-six consecutive patients with VVS were randomized to treatment with placebo, propranolol, or fluoxetine and followed-up for 6 months. Before and during treatment, they reported their syncopal and presyncopal episodes and graded their well-being,...

1 Characterization of the ,B-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion. 2 The gastric antisecretory effect of salbutamol was significantly blocked by propra...

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

OBJECTIVES We sought to assess the relative therapeutic efficacy of propranolol, nadolol and placebo in recurrent vasovagal syncope (VVS). BACKGROUND Central and peripheral mechanisms have been implicated in the pathogenesis of VVS. Propranolol, nadolol and placebo have different sites of action on central and/or peripheral mechanisms. It has not yet been clarified whether one of the aforemen...

Experts in the field recommend using nadolol at 1mg/kg/day and propranolol 2-3mg/kg/day for patients with long QT syndrome (LQTS), but there are no available studies defining most effective dose. In our experience, not all tolerate beta blocker full To describe institutional experience utilizing exercise stress testing (EST) subset of LQTS who did standard beta-blocker dosing. We queried Inheri...

The relationship between plasma propranolol concentration and relief of essential tremor was examined in 11 patients during treatment with oral racemic propranolol in doses of 30 to 640 mg/day. Although propranolol decreased tremor in all 11 patients, the degree of improvement varied widely in individuals (mean 51%, range 25--90%), and was not related directly occurred at plasma propranolol con...

Cerebral autoregulation and vasomotor responsiveness to carbon dioxide were measured quantitatively in normal baboons before and after intravertebral or intravenous infusion of the beta-adrenergic blocking agent, propranolol hydrochloride (Inderal®). Continuous measurements were made of cerebral blood flow (CBF: measured as bilateral internal jugular venous outflow using an electromagnetic flow...

The binding affinities of racemic derivatives of propranolol to ƒÀ-adrenoceptors were examined by means of radioligand binding assay to determine whether racemic propranolol shows biphasic binding to ,ƒÀ-adrenoceptors in a displacement experiment. Rat brain was used and the ƒÀadrenoceptor binding assay was carried out with 3H-dihydroalprenolol as the radioligand. A higher affinity of l-proprano...

1. Racial differences in propranolol enantiomer kinetics following oral dosing were previously documented in our laboratory. The purpose of this study was to more completely describe propranolol kinetics in black and white subjects with the goal of gaining a better understanding of the mechanism(s) responsible for racial differences in oral propranolol kinetics. 2. Twelve white and 13 black hea...

The effects of propranolol (DL-propranolol) and D-propranolol on thyroid hormone metabolism were studied in six euthyroid volunteers receiving L-thyroxine (T4) and six hypothyroid patients receiving T4 replacement. D-propranolol as well as propranolol decreased L-triiodothyronine (T3) concentrations and the ratio of T3 to T4 in the euthyroid subjects, and D-propranolol decreased these variables...