Preliminary Communications MEDICBJOURNAL 291 Phree radioactive compounds could be detected in chromato-grams of the urine after administration of 35S methimazole, of which two were probably 35S methimazole and VISO4. The third compound could be detected at the origin after the urinary sulphate had been removed by precipitation with barium chloride. After administration of propylthiouracil chror...

Graves’ disease is the most common cause of hyperthyroidism during pregnancy. Propylthiouracil (PTU) is the treatment of choice due to its relative safety during pregnancy compared to methimazole. However, rarely, PTU causes serious complications like hepatitis. We report a case of hepatitis possibly related to PTU during pregnancy complicated by thyrotoxicosis.

The authors report the case of a 10-year-old girl with Graves' disease (GD), treated with propylthiouracil, who developed uveitis and polyarticular arthritis, and whose mother also had GD and discoid lupus. The differential diagnosis of inflammatory arthritis that appears in a child with autoimmune thyroid disease managed with antithyroid drugs is discussed.

In this study, we present a 55-year-old female patient who suffered from atrial septal defect (ASD) and retrosternal toxic goitre simultaneously. The patient had been treated with a 300 mg/day dose of propylthiouracil for 20 days prior to operation. This patient has been operated on for both disorders and has recovered.