OBJECTIVE To determine whether the rate of change in total serum prostate-specific antigen (PSA) levels accurately detects prostate cancer and to evaluate whether it adds any predictive value to a single measurement of serum PSA alone, in general practice settings. MATERIALS AND METHODS A retrospective cohort of 219,388 community-dwelling men, aged ≥45 years, enrolled in the Kaiser Permanente...

Variation Among Primary Care Physicians in Prostate-Specific Antigen Screening of OlderMen Noorganization recommends prostate-specific antigen (PSA) screening inmenolder than75years.Nevertheless, testingrates remain high.1,2 We hypothesized that primary care physicians (PCPs) would vary substantially in PSA screening rates and that much of the variance in whether an older man received a PSA tes...

negative impact on quality of life [2-5]. Serum Prostate Specific Antigen (PSA) is a globally used screening tool for carcinoma prostate, based on which prostate biopsy largely recommended when PSA value exceeds 4 ng/ mL [6]. PSA blood level variation had been studied with respect to numerous factors including age, race, prostate volume (PV), androgen level, body mass index (BMI), creatinine, l...

background and objective: non-specific granulomatous prostatitis is an uncommon diffuse inflammatory condition of the prostate. it is important because it may be mistaken for prostatic carcinoma. the aim of the study was to determine the prevalence of non-specific granulomatous prostatitis (nsgp) and comparing the results of transrectal ultrasonography, serum prostate specific antigen (psa) and...

BACKGROUND Early detection of prostate cancer (CaP), the most prevalent cancer and the second-leading cause of death in men, has proved difficult, and current detection methods are inadequate. Prostate-specific antigen (PSA) testing is a significant advance for early diagnosis of patients with CaP. CONTENT PSA is produced almost exclusively in the prostate, and abnormalities of this organ are...

Systemic inflammation and immune responses are reported to be associated with progressive prostate cancer. In this study, we explored which among the fractions of white blood cell (WBC) and C-reactive protein (CRP) level were associated with high Gleason score prostate cancer. Prostate needle biopsy was performed in 966 men with suspicion of prostate cancer. We assessed age, serum prostate-spec...

Prostate cancer is the most frequently diagnosed cancer among men in the United States. The prostate-specific antigen (PSA) blood test is the most commonly utilized test to detect early prostate malignancy. Elevated PSA levels suggest to providers the possibility that their patients are at a higher statistical risk of harboring asymptomatic, organ-confined prostate cancer. Although PSA testing ...

AIM We evaluated the influence of ratio between free-to-total prostate specific antigen (F/T PSA) and prostate specific antigen density (PSAD)-(F/T)/PSAD on reduction of unnecessary prostate biopsies in grey zone (prostate specific antigen (psa) value 4.0-10.0 ng/ml). METHODS The study included 108 patients. For all patients serum total PSA (T PSA), free PSA (F PSA), F/T PSA and PSAD were ana...

BACKGROUND To evaluate the impact of poor glycemic control of type 2 diabetes mellitus (T2DM) on serum prostate-specific antigen (PSA) concentrations in men. METHODS We performed a prospective analysis of 215 consecutive patients affected by erectile dysfunction (ED). ED was evaluated using the IIEF-5 questionnaire and the poor glycemic control (PGC) of T2DM was assessed according to the HbA1...