background: prostate specific antigen (psa) has been used as a screening test for the early detection of prostate cancer (pc) for many years. although the introduction of psa test led to a considerable increase in reported prostate cancer cases, there is still some controversy over the sensitivity and specificity of this marker in distinguishing pc patients from those with benign prostate hyper...

growth of the prostate gland, also development of benign prostatic hyperplasia (BPH) is an androgen-dependent functions. Testosterone plays a major role in the prostate gland. Rat prostate gland is one of the most widely used models of animals in investigation. The rat prostate gland consisted of five lobes; the ventral, anterior, dorsal, lateral type 1 and latteral type 2. The goal of present ...

PURPOSE This study examined the seminal vesicle fluid (SVF) as a potential local source of insulin-like growth factor-I (IGF-I) in the peripheral zone of the prostate. EXPERIMENTAL DESIGN IGF-I levels in seminal fluid were measured. The levels of the IGF-I receptor (IGF-IR) in its active, phosphorylated form as well as direct downstream targets were examined in the peripheral zone of the pros...

The proapoptotic protein encoded by Par4 (prostate apoptosis response 4) has been implicated in tumour suppression, particularly in the prostate. We report here that Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-...

Prostatic enlargement due to benign adenomatous hyperplasia is very common in elderly males. However, benign mesenchymal tumors especially true leiomyoma of the prostate are rare. We describe a 68-year-old male presenting a urinary obstruction lasting more than two years. The patient was referred for an acute urinary retention. The clinical examination was normal. The perrectal examination reve...

Nerve growth factor (NGF) has been found in the normal prostate of the Wistar rat and is regarded as an important prostatic mitogen. We have previously shown that chronic stress induced epithelial hyperplasia while sympathetic denervation caused atrophy in the male Wistar rat prostate. NGF may have been a contributing mechanism to the hyperplasia and atrophy response that was observed. The aim ...

INTRODUCTION Prostatic gland basal cell proliferations exhibit morphological continuum ranging from basal cell hyperplasia to basal cell carcinoma. In the following report, we described clinical features, morphological spectrum, neuroendocrine differentiation and histogenesis of prostatic gland basal cell carcinoma in our patient. CASE REPORT Hematoxylin-eosin (HE), Alcian blu-periodic acid s...

Clinical BPH as a disease has been defined as benign prostatic enlargement (BPE) [1,2]; however in clinical practice we still see many patients with no enlargement, with prostate volume less than 20 g still causing symptoms and obstruction [3]. How can this be explained? To solve the puzzle, we first need to redefine clinical BPH. We need to go back to the basic fundamental pathology of BPH, wh...

The current report presents the case of a 42-year-old male with extraordinarily salient urination difficulty that had lasted 6 months. Transrectal ultrasonography and pelvic magnetic resonance imaging demonstrated prostatic hyperplasia and cyst. PSA level was 20.65 (>4) μg/L in the patient. Transrectal prostatic biopsy revealed benign prostatic hyperplasia. He agreed to receive plasmakinetic re...