We have assessed the feasibility of using fixed-limit criteria based on medical relevance and biological variation for evaluating the analytical performance of the prostate-specific antigen (PSA) test. The estimated within-subject variation of serum PSA is on the order of 10-20% at clinical decision points. The calculated performance goals of 5-10% CV are attainable with current immunoassay tec...

We report a case of elevated serum prostate-specific antigen-like immunoreactivity in a man with a disseminated pancreatic carcinoma.

Prostate specific antigen (PSA) testing is now a routine part of the investigation of men with suspected prostate cancer. While a very useful test it still has its problems, in particular its lack of specificity means abnormal results are often caused by benign disease. This review describes the current problems with PSA testing in prostate cancer diagnosis and highlights potential ways in whic...

Introduction: Prostate cancer is the utmost communal type of in adult men. Assessment serum total prostate specific antigen (PSA) broadly cast-off as a screening assistance prompt diagnosis prostate. Irrespective size or patient’s age, 25% cut off value set less free PSA level percentage suggested for cases with values amid 4.1 and 10 ng/ml; This helps detecting cancers 95% prevent 20% unnecess...

We report the first use of a commonly used ELISA colorimetric substrate as a SERRS marker and show how it can be used for the detection of pg ml(-1) levels of human prostate specific antigen (PSA) in clinical samples. The technique is amenable over a wide range of concentrations and lends itself to future multiplexing analysis.

AIM To review current data available on use of prostate specific antigen for screening healthy men for prostate cancer. METHODS Literature was reviewed and the guidelines from, American cancer Society, American Urologic Association was reviewed. RESULTS Current screening protocols lead to over diagnosis of prostate cancer. This often results in unnecessary biopsy procedures and treatments. ...

Background. The use of prostate-specific antigen test has markedly increased in Danish general practice in the last decade. Despite the national guidelines advice against PSA screening, opportunistic screening is supposed to be the primary reason for this increased number of PSA tests performed. Aims. Based on the increase in the amount of PSA conducted, we aimed to analyse how GPs in Denmark u...

background: stereotactic body radiotherapy (sbrt) has emerged as an effective treatment for localized prostate cancer. however, prostate-specific antigen (psa) kinetics after sbrt has not been well characterized. the objective of the current study is to analyze the rate of psa decline and psa nadir following hypofractonated sbrt in localized prostate cancer. materials and methods: from 2008 to ...

Objective(s): Prostate cancer (PC) is the most common cancer in men over 50 years of age. Bone scintigraphy is still performed in many institutions at the time of primary diagnosis. We aimed to evaluate the role of bone scan in the primary staging of PC in regard of different risk groups. Methods: A retrospective analysis of bone scans i...