Vishnu Menon and Mala Rao. II Classification and mechanism of proteases. III Protease.Aspartic proteases are a catalytic type of protease enzymes that use an activated water molecule bound to one or more aspartate residues for catalysis of their.response systems, to regulate cell growth, tissue homeostasis, remodeling, and j3. Aspartic Acid Proteases as Therapeutic Targets. Ghosh.cases. The gas...

BACKGROUND Proteases facilitate several steps in cancer progression. To identify proteases most suitable for drug targeting, actual enzyme activity and not messenger RNA levels or immunoassay of protein is the ideal assay readout. MATERIALS AND METHODS An automated microtiter plate assay format was modified to allow detection of all four major classes of proteases in tissue samples. Fifteen s...

Proteases: The Tip of the Iceberg peptide-bond hydrolysis represent one of the largest known functional classes of proteins. Through the catal-Proteases of Infectious Agents ysis of an essentially irreversible reaction they regulate Edited be exploited in the drug design process. With new pathogenic targets for drug design that the editor CD-ROM $250.00 compiled the book Proteases of Infectious...

Proteases represent the class of enzymes which occupy a pivotal position with respect to their physiological roles as well as their commercial applications. They perform both degradative and synthetic functions. Since they are physiologically necessary for living organisms, proteases occur ubiquitously in a wide diversity of sources such as plants, animals, and microorganisms. Microbes are an a...

The diverse roles of plant proteases in defence responses that are triggered by pathogens or pests are becoming clearer. Some proteases, such as papain in latex, execute the attack on the invading organism. Other proteases seem to be part of a signalling cascade, as indicated by protease inhibitor studies. Such a role has also been suggested for the recently discovered metacaspases and CDR1. So...

Proteases are defined as enzymes that have the ability to perform the hydrolysis of peptide bonds. Owing to this characteristic, proteases were initially described as nonspecific enzymes of protein catabolism, participating in processes such as tissue destruction or degradation of dietary proteins. More recently, a better understanding of their functions has allowed consideration of proteases a...

The identification of novel targets for controlling the sheep blowfly is an important process for discovering new generation compounds that are safer and more environmentally friendly. Experiments in our laboratory have indicated a role for serine proteases in influencing egg hatching in the sheep blowfly. Isolation of the proteases involved using benzamidine affinity chromatography identified ...

Proteases are enzymes integral to the plant immune system. Multiple aspects of defence are regulated by proteases, including the hypersensitive response, pathogen recognition, priming and peptide hormone release. These processes are regulated by unrelated proteases residing at different subcellular locations. In this review, we discuss 10 prominent plant proteases contributing to the plant immu...

The bulk of Earth's biosphere is cold (<5 °C) and inhabited by psychrophiles. Biocatalysts from psychrophilic organisms (psychrozymes) have attracted attention because of their application in the ongoing efforts to decrease energy consumption. Proteinases as a class represent the largest category of industrial enzymes. There has been an emphasis on employing cold-active proteases in detergents ...

Plant genomes encode hundreds of proteases, which represent dozens of unrelated families. The biological role of these proteases is mostly unknown, but mutant alleles, gene silencing, and overexpression studies have provided phenotypes for a growing number of proteases. The aim of this review is to show the diversity of the processes that are regulated by proteases, and to summarize the current...