conclusions the comprehensive analysis of a protein with important roles has never been easy, and in case of e2 envelope glycoprotein of hgv, there is no much data on its molecular and immunological features, clinical significance and its pathogenic potential in hepatitis or any other gbv-c related diseases. so, results of the present study may explain some structural, physiological and immunol...

cerebral venous thrombosis, including thrombosis of cerebral veins and major dural sinuses, is an uncommon disorder in the general population. however, it has a higher frequency among patients younger than 40 years of age, patients with thrombophilia, pregnant patients or those receiving hormonal contraceptive therapy or has foreign body such as catheter in their veins or arterial system. in th...

recent studies show that, inflammation plays an important role in the initiation and progression of atherosclerosis and in the pathogenesis of acute cardiovascular events. there is a possible association between ventricular dysfunction following acute myocardial infarction and high sensitivity c-reactive protein (hs-crp) and uric acid. in this study we assessed the relationship between hs-crp a...

patients with diabetes mellitus (dm), experience significant morbidity and mortality from microvascular retinopathy, nephropathy and neuropathy. hyperglycemia can induce diabetic complications through multiple pathways. activation of protein kinase c (pkc) by hyperglycemia is one of the pathways which causes diabetic complications. effect of nifedipine (a calcium channel blocker), and polymyxin...

background: hypertrophic cardiomyopathy is a genetic disorder with a prevalence rate of 0.2% in the general population. it comes from mutations in sarcomeric proteins. cardiac myosin-binding protein c3 is one of the critical genes in hypertrophic cardiomyopathy (hcm) and sudden cardiac death, accounting for about 20% of hcm-causing mutations. genetic testing is recommended in patients with hcm....

background: polycystic ovary syndrome (pcos), a common endocrine disorder, is associated with infertility, menstrual dysfunction, hirsutism and frequent miscarriages. insulin resistance, as a major cause of pcos, represents a disorder with increase in inflammatory markers and risk of type 2 diabetes. we aimed to investigate whether inflammatory markers, including c-reactive protein and c3 (comp...

conclusions there were significant linkages between hcv genotypes and il28b genotypes/alleles. patients with a favorable il28b and genotypes 1 and 4 hcv infection stand a better chance to clear hcv in the acute phase. objectives this meta-analysis was designed to determine the world-wide distribution patterns of il28b genotypes and alleles, and to find possible linkages between il28b and hcv ge...

background sepsis is one of the most important causes of morbidity and mortality in the intensive care units (icus). it is difficult to accurately differentiate sepsis from similar diseases rapidly. therefore, it becomes critical to identify any biomarker with the ability of differentiation between sepsis and nonsepsis conditions. the urokinase plasminogen activator receptor has been implicated...

conclusions while the crp value was in patients with acute brucellosis in the current study, the mpv, rdw and leukocyte counts were within the normal range. crp value remains the most valuable inflammatory marker in cases of acute brucellosis. results the follow-up within the year after treatment was examined. the values of age, gender, leukocyte count, c-reactive protein, rdw and mpv were reco...