نتایج جستجو برای: protein degradation
تعداد نتایج: 1347096 فیلتر نتایج به سال:
The degradation of cellular proteins in fibroblasts, both those of rapid and those of slow turnover rates, was inhibited by low concentrations of chloroquine or neutral red in the medium. Cells inhibited by chloroquine can be inhibited further by fluoride. Chloroquine was taken up by the fibroblasts and the concentration in the cells reached several hundred times that in the medium. Isopycnic f...
Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing in cancer cells leads to chemoresistance and cancer progression, in part due to p53 inhibition. Recently, hyperglycemia has been shown to redu...
The aim of this study was to investigate the effects of various doses of essential oils (EO) of thyme (TEO) or cinnamon (CEO) on in vitro rumen degradation of protein of a commercial total mixed ratio (TMR) containing 16.4% crud protein (CP). Treatments were TMR without any of EOs (control); control plus 25 µL of TEO (TEO25); control plus 50 µL of TEO (TEO50); control plus 25 µL of CEO (CEO25) ...
Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy an...
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