The strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection viruses in permissive cells, but its role HSV-1 life cycle is still unclear. Here, we demonstrated that immediate early (IE) gene ICP4 inhibits kinase A (PKA) phosphorylation induce Rap1b-activation-mediated ...

Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of residues. This review summarizes the expression role RPTPs cancer illustrates signaling pathway mechanisms effecting oncogenesis, progression, prognosis, angiogenesis, so as to provide more ef...

Introduction: Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer’s disease. Triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. In this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (TEDMT) on H2O2-...

Background: Mutation of p53 is a frequent event, and mutant exhibits low levels acetylation phosphorylation. This study aimed to investigate the effect histone deacetylase (HDAC) inhibitor, 4-hexylresorcinol (4HR), on phosphorylation carcinoma cells its therapeutic effects in xenograft model. Methods: To determine 4HR p53, western blot analysis was performed using YD-9 YD-15 cells. siRNA used e...