We describe the cases of 2 men with chronic combat-induced post-traumatic stress disorder (PTSD) who benefited from therapy with ziprasidone. They did not have active psychotic symptoms. Both the patients had a history of inadequate response to previous trials of different psychotropic agents. Ziprasidone was considered because of its broad-spectrum actions on various neurotransmitters. To our ...

The use of psychotropic agents is widespread, as is evident from the fact that many patients have been treated with them since their introduction. Concepts of the relationship between the actions of psychotropic drugs and the functions of specific brain systems have particularly progressed through the relatively brief history of psychopharmacology. Furthermore, efforts to provide explanations f...

Background: We performed an epidemiologic study to analyze nationwide time trends in adult psychotropic drug use over a period from 2006 to 2012, and to identify those factors associated with the likelihood of consumption of these drugs during the study period; Methods: Cross-sectional study on psychotropic medication in the Spanish adult population. We used secondary individualized data drawn ...

BACKGROUND Time-trend studies on psychotropic drugs among children and adolescents are scarce, and most of them are outdated. The purpose of this study was to study prevalences of psychotropic drug use during 2004-2014 among Norwegians aged <18 years, overall and in psychotropic sub-groups. METHODS Data were obtained from the Norwegian Prescription Database, which covers all dispensed prescri...

BACKGROUND Psychotropic drugs are commonly utilised among the elderly. This study aimed to analyse whether two socioeconomic determinants - income and marital status - are associated with differences in utilisation of psychotropic drugs and potentially inappropriate psychotropic drugs among elderly in Sweden. METHODS All individuals aged 75 years and older who had purchased a psychotropic dru...

Psychotropic drugs are not necessarily the drugs of psychiatry. Seventy percent of antidepressants, and 90% of anxiolytics are prescribed by nonpsychiatric physicians. Since psychotropic medications are so frequently employed by nonpsychiatric physicians, e.g., neurologists, primary care physicians, internists, and because large numbers of their patients are concurrently on medical drugs for so...

Paradigm strain exists in psychiatric pharmacology. The prevailing monoamine-based psychotropic agents have in some circumstances saved lives, robustly benefitted patient reported outcomes (e.g., quality of life measures, functionality), and have facilitated reintegration and recovery. Unfortunately, these foregoing desirable outcomes are an uncommon occurrence for most individuals who receive ...

Neuroprotective therapies for neurodegenerative diseases (NDDs) have proven elusive. The established psychotropic agents commonly used to treat the neuropsychiatric manifestations of NDDs are potential neuroprotective therapies, and neuropsychiatrists and others may benefit from a knowledge of the neuroprotective properties of these medications. This report identifies FDA-approved, first-line p...