BACKGROUND Pulmonary edema plays a pivotal role in the pathophysiology of respiratory syncytial virus (RSV)-induced respiratory failure. In this study we determined whether treatment with TIP (AP301), a synthetic cyclic peptide that mimics the lectin-like domain of human TNF, decreases pulmonary edema in a mouse model of severe human RSV infection. TIP is currently undergoing clinical trials as...

We measured extravascular lung water (EVLW) by the thermal-dye technique in a broad group of critically ill patients who had either acute cardiac or noncardiac illnesses. A portable AP supine chest roentgenogram, reviewed blindly, was used to classify patients as to the presence or absence of pulmonary edema; by clinical history we categorized patients into either a cardiac or noncardiac (ie, A...

BACKGROUND Diagnosing the underlying cause of acute dyspnea can be challenging. Lung ultrasound may help to identify pulmonary edema as a possible cause. OBJECTIVE To evaluate the ability of residents to recognize pulmonary edema on lung ultrasound using chest radiographs as a comparison standard. METHODS This is a prospective, blinded, observational study of a convenience sample of residen...

The relationship of serum colloid osmotic pressure (COP) and pulmonary artery wedge pressure (PAWP) to pulmonary edema and mortality was investigated in 76 critically ill patients. Forty patients suffered from circulatory shock and 36 dId not. The COP-PAWP gradient and radiographic evidence of pulmonary edema were measured at the time of diagnosis. The COPPAWP gradient was markedly decreased in...

The authors present the case of a patient with noncardiogenic pulmonary edema as a result of urosepsis. We explain the physiologic and radiographic differences between cardiogenic and noncardiogenic pulmonary edema. We also discuss some specific types of pulmonary edema and the radiographic findings that are commonly present. In addition, we define sepsis and the physiologic effect that it has ...

BACKGROUND The physiological changes associated with pregnancy may predispose pregnant women to pulmonary edema. Other known causes of pulmonary edema during pregnancy include tocolytic drugs, preeclampsia, eclampsia, and peripartum cardiomyopathy. METHODS We describe a rare case of pulmonary edema caused by takotsubo cardiomyopathy in a pregnant woman at 14 weeks of gestation who was undergo...

The electron microscopic alterations of the alveolar septum in advanced hemodynamic and alloxan-induced pulmonary edema were compared. Pulmonary edema was produced in anesthetized dogs by means of increased left atrial pressure and hemodilution and by alloxan administration. Sections of pulmonary tissue from these dogs and similarly anesthetized controls were processed for and examined by light...

The question of whether pulmonary edema develops during exercise on land is controversial. Yet, the development of pulmonary edema during swimming and diving is well established. This paper addresses the current controversies that exist in the field of exercise-induced pulmonary edema on land and with water immersion. It also discusses the mechanisms by which pulmonary edema can develop during ...

T he importance of the balance of lung fluid and pulmonary edema in experimental and clinical medicine explains the effort made in the last 30 years to measure lung water content and to develop clinically applicable methods. Pulmonary edema is an essential component ofthe spectrum oflung reactions to injury. As defined by the Starling equation,’ damage to the endothelium increases the permeabil...

The etiology of edema associated with pulmonary resection was investigated in five patients during the immediate postoperative period. Three patients received pneumonectomy while two patients had one lobe resected. All patients suffered from severe respiratory distress and had x-ray evidence of diffuse interstitial pulmonary edema within 12 hours of surgery. Hemodynamic data were obtained with ...