Th e goals of this review were to examine published data concerning glucocorticoid pulse therapy in general, as well as evidence-based treatment regimens in several neurological disorders. Th e aim of pulse therapy is achieving a stronger and more rapid therapeutic eff ect, and decreasing the need for longterm use of steroids. It is supposed that the action of supra pharmacological doses of glu...

Scleroderma is a generalized, multisystem disease in which characteristic vascular alterations are seen together with severe fibrosis of skin, synovium and certain internal organs, chiefly the intestinal tract, lung, heart and kidneys. An autoimmune etiology has been suggested by the clinical association with other diseases of presumed autoimmune etiology. The presence of Raynaud's phenomenon i...

High-dose intravenous methylprednisolone therapy has previously been shown to be efficacious in the treatment of renal lupus erythematosus. The present report presents 2 patients with life-threatening, nonrenal lupus erythematosus. One patient had coma and seizures, while the other had sever thrombocytopenia and anaemia. Both had failed to respond to oral corticosteroid therapy in high doses bu...

General application of continuous-wave (CW) laser irradiation modes in photodynamic therapy can cause thermal damage to normal tissues in addition to tumors. A new photodynamic laser therapy system using a pulse irradiation mode was optimized to reduce nonspecific thermal damage. In in vitro tissue specimens, tissue energy deposition rates were measured in three irradiation modes, CW, pulse, an...