Background and objective Hyperglycaemia remains a challenge in type 1 diabetes since current regimes used to determine meal insulin requirements prove to be ineffective. This is particularly problematic for meals containing high amounts of protein and fat. We aimed to determine the post-prandial glycaemic response and total insulin need for mixed meals, using sensor-augmented insulin pumps in c...

Method From July 2013 up to September 2014 four high risk patients with low EF below 30 %, concomitant mitral valve disease (3 pts), ventricular aneurism (1 pt), and severe coronary artery disease were operated using on pump beating heart technique. Al pts were first connected to the IABP through the femoral artery and then put on CPB machine with a double venous cannula in the superior and inf...

BACKGROUND Since the late 1960s, coronary artery bypass graft (CABG-only) procedures were traditionally performed using a heart-lung machine on an arrested heart (on-pump). Over the past decade, an increasing number CABG-only procedures were performed on a beating heart (off-pump). Advocates of the off-pump approach expect to reduce many of the adverse side effects related to using the heart-lu...

Oxaliplatin is first-line chemotherapy for colorectal cancer, but produces dose-limiting neurotoxicity. Acute neurotoxicity following infusion produces symptoms including cold-triggered fasciculations and cramps, with subsequent chronic neuropathy developing at higher cumulative doses. Axonal excitability studies were undertaken in 15 oxaliplatin-treated patients before and immediately after ox...

INTRODUCTION Postoperative atrial fibrillation after isolated coronary revascularization has been associated with increased morbidity and mortality. Aim of present investigation was to evaluate incidence of postoperative atrial fibrillation and its prognostic role in patients undergoing isolated coronary artery by-pass and disclose possible differences between off-pump and cardiopulmonary assis...

Off-pump surgery was the original approach to treating patients with cardiac disease in the era before cardiopulmonary bypass. With the advent and refinement of cardiopulmonary bypass, the use of this technique fell out of favor and was quickly surpassed by on-pump techniques. However, the limitations of bypass surgery, especially for coronary artery bypass procedures, was still significant, le...

BACKGROUND Metabolic dysfunctions characteristic of overt hypothyroidism (OH) start at the early stage of subclinical hypothyroidism (SCH). Na⁺/K⁺-ATPase (the sodium pump) is a transmembrane enzyme that plays a vital role in cellular activities in combination with membrane lipids. We evaluated the effects of early changes in thyroid hormone and membrane cholesterol on sodium pump activity in SC...

introduction: coronary artery disease (cad) is the most common type of heart disease, with a mortality rate of 385,000 person per year in the united states. there are two main methods for cad treatments: angioplasty and bypass surgery. coronary artery bypass grafting (cabg) is one of the greatest surgical operations of the 20th century and it is presented as most effective and long-term therapi...

Introduction: Coronary artery disease (CAD) is the most common type of heart disease, with a mortality rate of 385,000 person per year in the United States. There are two main methods for CAD treatments: angioplasty and bypass surgery. Coronary Artery Bypass Grafting (CABG) is one of the greatest surgical operations of the 20th century and it is presented as most effective and long-term therapi...