نتایج جستجو برای: purine metabolism
تعداد نتایج: 233577 فیلتر نتایج به سال:
Although many countries now have programs to lower the levels of lead in the environment, human exposure to Pb remains of concern to public health officials worldwide. The mechanisms of lead toxicity are still not fully understood, but recent findings have recognized the significance of the lead-induced impairment of the cell energy metabolism. This review outlines recent hypotheses and evidenc...
Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Although this biochemical defect reconfigures purine metabolism and leads to elevated levels of the breakdown product urea, it remains unclear exactly how loss of HPR...
Metabolism is the major output of the circadian clock in many organisms. We developed a computational method to integrate both circadian gene expression and metabolic network. Applying this method to zebrafish circadian transcriptome, we have identified large clusters of metabolic genes containing mostly genes in purine and pyrimidine metabolism in the metabolic network showing similar circadia...
The enzymatic reactions responsible for the interconversion of purine nucleotides and for the biosynthesis of the imidazole ring of histidine in bacteria have been described previously (4-7). This study of the isolated enzymes not only revealed the chemical nature of the reactions but also suggested mechanisms for their regulation. The study of purine metabolism described in the present paper w...
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