In the title compound, C(24)H(22)BrNO(3), the dihydro-pyran ring adopts a half-chair conformation, whereas the pyrrolidine ring is in an envelope conformation. The bromo-phenyl group is oriented at an angle of 66.44 (4)° with respect to the naphthalene ring system. In the crystal structure, mol-ecules are linked into centrosymmetric dimers by C-H⋯π inter-actions and the dimers are connected via...

In the title compound, C28H23N3O2, the pyrazole ring makes a dihedral angle of 16.90 (6)° with the phenyl ring to which it is attached. Both di-hydro-pyran rings exhibit half-chair conformations. Intramolecular C-H⋯O interactions generate S(6) and S(8) ring motifs. In the crystal, weak C-H⋯O and C-H⋯π interactions occur.

An overview of the synthesis of the fungal metabolites (+)-dermolactone, (-)- semixanthomegnin, (+)- and (-)-mellein, (-)-ochratoxin alpha, (-)-(1R,3S)-thysanone, the enantiopure ventiloquinones L, E and G, and 8-desmethyleleutherin from a common chiral intermediate, is presented. Further methodology leading potentially toward extended quinones such as (3S,3'S)-xylindein is also outlined.

In the title compound, C(20)H(29)NO(8)S, the two five-membered rings adopt envelope conformations (with an O atom at the flap in each case), while the six-membered pyran ring displays a twist-boat conformation. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into a supra-molecular chain running along the a axis.

In the title compound, C19H14FN3O3, the central pyran ring adopts a boat conformation with the O atom and the quaternary C atom diagonally opposite displaced by 0.068 (1) and 0.075 (1) Å, respectively, above the mean plane defined by the other four ring atoms. The co-planar atoms of the pyran ring and the fluoro-phenyl ring are nearly perpendicular, as evidenced by the dihedral angle of 87.11 (...

In the mol-ecule of the title compound, C(21)H(22)N(2)O(5), the indole system and the spiro-pyran ring are almost planar [maximum deviations of 0.0447 (17) and 0.0781 (17) Å, respectively]; the dihedral angle between them is 84.6 (3)°. The remaining six-membered ring adopts a twisted conformation. Intra-molecular N-H⋯O hydrogen bonds occur. In the crystal structure, intera-molecular N-H⋯O and C...

In the title compound, C(13)H(12)O(3), the pyran ring adopts a half-chair conformation with a C atom deviating from the least-squares plane of the remaining ring atoms by 0.606 (2) Å. This plane and that of the benzene ring make a dihedral angle of 44.18 (6)°. In the crystal, mol-ecules are linked through O-H⋯O hydrogen bonds into infinite chains along the b axis, and these chains are cross-lin...

The title compound, C21H14O3, crystallizes with eight independent mol-ecules (A-H) in the asymmetric unit which are arranged in four groups of two mol-ecules each (AB, CD, EF and GH). In each mol-ecule, the pyran-2-one ring is planar (r.m.s. deviations vary from 0.001 to 0.017 Å), while the pyran ring has a screw-boat conformation. In the crystal, mol-ecules stack in two columns, along the [10-...

In the title compound, C10H17IO5, the six-membered tetra-hydro-pyran ring and the five-membered 1,3-dioxolane ring adopt sofa and envelope conformations, respectively. In the crystal, O-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into layers nearly parallel to the bc plane.

In the crystal structure of the title compound, C(21)H(15)N(5)O(2), the planar indolone unit and the pyran ring are almost perpendicular to each other [dihedral angle = 89.41 (2)°], and the pyrazole and phenyl rings are oriented at an angle of 25.74 (1)°. The mol-ecular packing is stabilized by inter- and intra-molecular C-H⋯O, N-H⋯O and C-H⋯π hydrogen bonds.