A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coron...

BACKGROUND Special diphenyl-pyrazole compounds and in particular anle138b were found to reduce the progression of prion and Parkinson's disease in animal models. The therapeutic impact of these compounds was attributed to the modulation of α-synuclein and prion-protein aggregation related to these diseases. METHODS Photophysical and photochemical properties of the diphenyl-pyrazole compounds ...

In the title compound, C(27)H(19)N(3)O(4), the phenol and pyrazole rings are almost coplanar [dihedral angle = 0.95 (12)°] due to an intra-molecular O-H⋯N hydrogen bond, whereas the phenyl ring is tilted by 40.81 (7)° with respect to the plane of the pyrazole ring. The aromatic ring with a nitro-phen-oxy substituent makes a dihedral angle of 54.10 (7)° with the pyrazole ring.

ABSTRACT. The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) and papain-like (PLpro) prevents viral multiplications. Molecular docking, absorption, distribution, metabolism, excretion, toxicity (ADMET) studies pyrazole-indole molecules 6a, b, Schiff bases 8a, pyrazolo[1,5-a]pyrimidines 10a, b were performed done. Based on the molecular docking st...

The replacement of one pyrazole ligand by 2-aminopyridine in previously known rhenium tricarbonyl pyrazole complexes leads to more selective anion hosts.

The effects of pyrazole, which is known to induce hepatic cytochrome P4502A5 (CYP2A5) through posttranscriptional mechanisms, on the level of CYP2A5 in liver and extrahepatic tissues were examined in this study. Intraperitoneal administration of pyrazole at 200 mg/kg for 3 days induced CYP2A4/5 mRNAs and proteins and microsomal coumarin 7-hydroxylation activity in liver and kidney of C57BL/6 mi...

There is current interest in the bioinorganic chemistry of gallium owing to the extensive use of the element in medicine both as a therapeutic and diagnostic agent [1]. After numerous studies of simple gallium(III) salts [2, 3] recent investigations have focussed on coordination compounds of gallium halides with bio-relevant ligands including also many of the common nitrogen heterocycles [3, 4]...

this work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1h-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-fe2o3 nanoparticles. eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily availa...