Various effects of harmidine hydrochloride, an alkaloid of Peganum harmalla, have been studied in rats treated with harmidine hydrochoride 12 mg/kg body weight alone and pretreated with pyridoxine. Harmidine produced shivering, ataxia, diarrhoea, reduction in motor activity, loss of postural reflex and hypothermia. Weight of animals, respiratory rate, heart rate, urinary output, oestrous cycle,...

Isotopic data reported by Mead, Steinberg, and Howton in 1953 (1) and by Steinberg, Slaton, Howton, and Mead in 1956 (2) firmly established the incorporation of acetate and of linoleate, respectively, into arachidonic acid in the rat. Witten and Holman in 1952 (3) had suggested that pyridoxine stimulated this conversion. They had shown that rats deficient in essential fatty acids and in pyridox...

Pyridoxine hydrochloride is water-soluble B vitamin widely used for the prevention and treatment of vitamin B6 deficiency and other several diseases. The aim of this study was to explore the effect of The Trivedi Effect Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of pyridoxine hydrochloride using PXRD, PSA, DSC, and TGA/DTG analysis. Pyridoxine hydroc...

To The ediTor Recently, Lin and colleagues have reported a case of pyridoxine-dependent seizures in this journal 1. The diagnosis was based upon the clinical criteria as formulated by Baxter 2. In discussing the case the authors state that the underlying pathophysiology of the disorder is unknown and that no biochemical aids are available in establishing the diagnosis. Indeed, for 50 years pyri...

S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...

A cutaneous reaction termed palmar-plantar erythrodysesthesia (PPES) or hand-foot syndrome can be dose limiting for Doxil, a doxorubicin containing pegylated (Stealth) liposome. The objective of this study was to determine the ability of concomitant pyridoxine therapy to prevent the development of PPES during Doxil therapy. Forty-one dogs with non-Hodgkin's lymphoma were randomized in a double-...

Recently a case of an infantile hypophosphatasia (HPP) patient was published [1]. We would like to report supplemental data that were collected during the first 2 months of his life, when patient was admitted at our neonatal ward because of seizures. After a first period of seizures, successfully treated with a single gift of phenobarbitone, pyridoxine and midazolam, patient went home at day 7....

Oral glucose tolerance tests were carried out in 16 clinically normal subjects with pyridoxine deficiency (as adjusted by red cell transaminase activity and the 6h tryptophan load test), and in 16 nondeficient controls. The deficient subjects had fasting normoglycemia with hypoinsulinemia (p less than 0.01), and a normal postglucose increment in insulin, but peak blood glucose and incremental g...

Pyridoxine dependent seizures is a rare autosomal recessive disorder. Its manifestations are intractable epilepsy leading to death in status epilepticus. Treatment with pyridoxine prevents the seizures and normalizes the EEG. Early diagnosis is important for the intellectual outcome. In Denmark, the disease has occurred in a child of healthy Tamil immigrants, who are first cousins. The child's ...