In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) and 3,4-dihydro-2H-benzo[4,5]isothiazolo[2,3-a]pyrimidine are the heterocyclic antiretroviral agents against human immunodeficiency virus type 1 (HIV-1) infection. On the basis of similar structure-activity relationships of anti-HIV activities toward the early-stage of viral infection between these unique scaffolds, the tran...

The titled compounds were prepared by interaction of ethyl 2-(benzo[d]thazol-2-yl)acetate (3) with different arylidinemalononitrile derivatives (4a-c) in EtOH/TEA solution at room temperature. When 3 was treated with 2(ethoxymethylene)-malononitrile (4f) under same reaction conditions, the ethyl iminothiazolopyridine-4-carboxylate (6) was obtained. Ethyl (amino(methoxy)methyl)-3-(substitutedphe...

The breakdown of thiamine by the action of shellfish thiaminase was demon strated by Fujita et al. (1) to be a base exchange reaction. Thereafter, other type of thiaminase which decomposes thiamine into 2-methyl-4-amino-5-hydroxymethylpyrimidine (Pm-CH2OH) and 4-methyl-5-ƒÀ-hydroxyethylthiazole (Th) was discovered. Then, thiaminase was classified into a base exchange type (Thiaminase ‡T) and a ...

The hexanucleotide d(CGTACG) has been synthesized by a phosphotriester method in which, for the first time, an O-6 protected deoxyguanosine derivative has been used to avoid side reactions of the guanine residues. Conformational analysis by circular dichroism shows that d(CGTACG) maintains a B form under conditions (5 M NaCl) where the all C/G hexanucleotide d(CG)3 adopts a Z form, even though ...

In the title pymiridine-2,4-dione derivative, C14H16N2O2S, the dihedral angle between the six-membered rings is 66.69 (10)°. The mol-ecule is twisted about the Cp-S (p = pyrimidine) bond, with a C-S-C-N torsion angle of -19.57 (16)°. In the crystal, adjacent mol-ecules form inversion dimers through pairs of strong N-H⋯O hydrogen bonds, generating an R 2 (2)(8) ring motif. The dimers are connect...

Reaction of 2-(methyl-sulfan-yl)pyrimidin-4-amine with the 5-(methoxy-vinyl-idene) derivative of Meldrum's acid and subsequent heating of the product in Dowtherm fluid yielded the title compound, C(8)H(7)N(3)OS, which was proven to contain a bicyclic 4H-pyrimido[1,6-a]pyrimidine system. All non-H atoms of the mol-ecule are coplanar within 0.15 Å. The bond-length distribution in the bicyclic cor...

Aim: To study the effects of pyrimidine derivative 4CPTP on cardiovascular system. Material and methods: Ionotropic and chronotropic effects of 4CPTP were studied using rabbit heart and frog’s heart ‘in situ’ preparation. Dog’s blood pressure preparation was used to assess the effects of 4CPTP on blood pressure. Results: The test compound, like phenobarbitone produced dose dependent decrease in...

2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with ethyl bromoacetate afforded the ester derivatives 4a and 4b, while their condensation with hydrazi...