Tässä artikkelissa tarkastelen metamodernia utooppisuutta kahdessa vuonna 2016 ilmestyneessä romaanissa, Emma Puikkosen Eurooppalaisissa unissa ja Riikka Pulkkisen Parhaassa mahdollisessa maailmassa, joita yhdistävät samankaltaiset muotoratkaisut Euroopan lähihistorian käsittely. Pyrin osoittamaan, kuinka romaanit koettavat ylittää postmodernin ironisen eetoksen aikamme utopianvastaisuus toisaa...

Head and neck squamous cell carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC mutation profiles including genes that control several cancer cell characteristics, including dysregulation of proliferation and death signals, induction of inflammatory responses, and reprogramming of cell metabol...

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The disease is characterized by self-limited inflammatory attacks of fever and polyserositis along with elevated acute phase reactants. FMF is inherited autosomal recessively; however, a significant proportion of heterozygotes al...

Introduction FMF is a monogenic autoinflammatory disease with recurring episodes of fever and serositis attacks. FMF is associated with mutations in pyrin. On the other hand mutations in a molecule in the same pathway, cryopyrin, is characterized by inflammatory features involving the inner ear as well. A study has suggested the involvement of cochlea in Behçet disease, which is a polygenic aut...

The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), respectively, and exon 2 encodes a proline and glycine-rich (PGR) domain. Here, ...

Introduction FMF is a monogenic autoinflammatory disease with recurring episodes of fever and serositis attacks. FMF is associated with mutations in pyrin. On the other hand mutations in a molecule in the same pathway, cryopyrin, is characterized by inflammatory features involving the inner ear as well. A study has suggested the involvement of cochlea in Behçet disease, which is a polygenic aut...