The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well their further modification are described in the present manuscript. It was shown that above-mentioned may be obtained via acylation initial corresponding acylhalides, cyclic anhydrides imidazolides acids monoesters. Obtained were converted into [1,2,4]triazolo[1,5-с]quinazolines used compound...

Some reactive dyes (6a-6l) having Quinazolin-4(3H)-one system have been synthesized by coupling of diazotized 3-(4-(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl) phenyl)-4-oxo-2-phenyl-3,4-dihydroquinazoline-6-sulphonic acid with cyanurated components such as H-acid, J-acid, N-methyl Gamma acid, Peri Sulpho Tobias Koch Bronners Chicago K-acid, N-Phenyl J-acid and M-acid. The were characterized nitrog...

Aim: Novel quinazolin-4(3H)-one heterocycles were synthesized and assessed for their anti-diabetic activity. Non-enzymatic glycosylation of haemoglobin assay was carried out to identify potential as anti-diabetic. The cyclization quinazolinone-4(3H)-one achieved, whereas carbon-carbon cross coupling reactions using Sonogashira Suzuki-Miyaura reaction conditions characterized with analysis. This...

Introduction: Quinazolin-4(3 H )-one derivatives have attracted considerable attention in the pharmacological profiling of therapeutic drug targets. The present article reveals development arylidene-based quinazolin-4(3 motifs as potential antimicrobial candidates. Methods: synthetic pathway was initiated through thermal cyclization acetic anhydride on anthranilic acid to produce 2-methyl-4H-3,...

The title compound {systematic name: spiro-[cyclo-pentane-1,2'(1'H)-quinazolin]-4'(3'H)-one]}, C(12)H(14)N(2)O, has been reported previously [Klemm, Weakley, Gilbertson & Song (1998 ▶). J. Heterocycl Chem. 35, 1269-1273]. Its structure has been redetermined at 113 K with greater precision for all data. The mol-ecule is built up from two fused six-membered rings and one five-membered ring linked...

4-amino-1-(beta-D-ribofuranosyl)quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2-one (7) using the Vorbruggen's silylation method and provided exclusively the beta-anomer. This quinazoline nucleoside and its 2',3'-O-isopropylidene derivative (9) did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-...

Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albi...

The title compound, C(15)H(14)N(2), was formed during the lithia-tion of 2-methyl-quinazoline with phenyl-lithium followed by hydrolysis of the inter-mediate lithium 2-methyl-4-phenyl-4H-quinazolin-3-ide. NMR spectra as well as single-crystal X-ray structural data indicate that the reaction product to have the same structure in chloro-form solution as in the crystalline state. The phenyl substi...