Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior selectivity compared the previously reported their NSAID analogue had equipotent as celecoxib. Compared celecoxib, 4 b, 7c, 13 b showed similar anti-inflammatory activity in vivo, whi...