نتایج جستجو برای: quinine
تعداد نتایج: 2987 فیلتر نتایج به سال:
The microstructure of the licking behavior of water-deprived rats presented with either water or quinine during 45-min single-bottle tests was analyzed. The chorda tympani (CT) and glossopharyngeal (GL) nerves, which innervate the taste buds of the tongue, were transected in deeply anesthetized rats to discern their contribution to the behavioral pattern of quinine drinking. Rats were presurgic...
A 23-year-old woman experienced six distinct episodes of severe combined neutropenia and thrombocytopenia. At least one of the episodes was accompanied by hemodialysis-requiring acute renal failure and fragmentation hemolysis (hemolytic uremic syndrome [HUS]). In retrospect, all episodes were probably associated with the ingestion of quinine. Quinine-dependent antibodies to platelets, neutrophi...
In combination with antibiotics, quinine is recommended as the second-line treatment for uncomplicated malaria, an alternative first-line treatment for severe malaria, and for treatment of malaria in the first trimester of pregnancy. Quinine has been shown to have frequent clinical failures, and yet the mechanisms of action and resistance have not been fully elucidated. However, resistance is l...
An assay was developed measuring the disruption of rosettes between Plasmodium falciparuminfected (trophozoites) and uninfected erythrocytes by the antimalarial drugs quinine, artemisinin mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. At 4 hr incubation rosettes were disrupted by all the drugs in a dose dependent manner. Artemisinin and quinine were the most effective anti-ma...
The emergence of chloroquine resistance, and a world-wide scarcity of quinine, have resulted in a search for newer antimalarial drugs directed against falciparum malaria. Allopurinol causes virtually complete inhibition of purine biosynthesis of malaria parasites, which may prove lethal to the parasites. This study was designed to examine if allopurinol is additive to quinine in the treatment o...
PURPOSE Leg cramps are common in patients with heart failure. Quinine is frequently prescribed in low doses to these patients, but safety of this practice is unknown. We studied the outcomes associated with use of quinine in a nationwide cohort of patients with heart failure. METHODS Through individual-level-linkage of Danish national registries, we identified patients discharged from first-t...
was a clear association with malaria, and that all these four cases responded well to treatment with quinine, whereas the other two patients were discharged with evidence of permanently damaged kidneys. Another report of his observations was published in 1942. His main evidence of the malarial origin of the subacute glomerular nephrosis which he described is the response to quinine, and thus he...
Sir,?Owing to the shortage of quinine by-hydrochloride may we draw attention to the following method of using quinine sulphate for intramuscular injections which we have found to be successful in malaria ? About 6,000 injections have been given in the past 12 months without any abscess formation and the therapeutic results have been as satisfactory as quinine bi-liydrochloride. Even infants, a ...
2. In all cases the results indicate that the total alkaloids have an effect similar to, or even better than, that of quinine. 3. Industrial and laboratory preparations are of equal value. 4. The total alkaloids from which the quinine has beenextractedhave apoortherapeutic effect, andthe difference between these and the results with the total alkaloids may be due to the synergistic action of sm...
The relationship between specific gustatory nerve activity and central patterns of taste-evoked neuronal activation is poorly understood. To address this issue within the first central synaptic relay in the gustatory system, we examined the distribution of neurons in the nucleus of the solitary tract (NST) activated by the intraoral infusion of quinine using Fos immunohistochemistry in rats wit...
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