OBJECTIVE Rabies is invariably a fatal encephalomyelitis that is considered to be a serious public health problem. It is necessary to develop standard rabies virus diagnostic tools, especially for diagnosing the strains prevalent in China. METHODS Monoclonal antibodies (MAbs) specific to rabies virus were produced and characterized by enzyme linked immunosorbent assay (ELISA), isotyping, affi...

OBJECTIVE To evaluate epidemiologic features of rabies virus variants in dogs and cats in the United States during 1999 and assess the role of bat-associated variants. DESIGN Epidemiologic survey. SAMPLE POPULATION Rabies viruses from 78 dogs and 230 cats. PROCEDURE Brain specimens from rabid dogs and cats were submitted for typing of rabies virus. Historical information, including owners...

Rabies is one of the infectious diseases, highly fatal and true zoonoses. The disease occurs in most countries. In Iran, rabies is endemic and a major public health Problem. The most warm- blooded animals are susceptible to rabies. The methods of transmission is almost always by the bite of an infected animal to human and animals. The saliva of rabid animal contains the rabies virus. The main s...

OBJECTIVE To evaluate the effectiveness of intervention efforts to halt 2 wildlife rabies epizootics from 1995 through 2003, including 9 oral rabies vaccination campaigns for coyotes and 8 oral rabies vaccination campaigns for gray foxes. DESIGN Retrospective study. ANIMALS 98 coyotes during prevaccination surveillance and 963 coyotes and 104 nontarget animals during postvaccination surveil...

The spread of rabies virus between adjacent mouse neuroblastoma cells was inhibited in the presence of spleen cells from mice sensitized to rabies virus as measured by the size of fluorescent focus formation. This activity of focus size reduction was appeared to be closely related to the deVelopment of cell-mediated cytotoxic activity. Rabies virus inactivated by beta-propiolactone was also cap...

BACKGROUND Rabies is an acute fatal encephalitis caused by all members of the Lyssavirus genus. The first human rabies survivor without benefit of prior vaccination was reported from Milwaukee in 2005. We report a second unvaccinated patient who showed early recovery from rabies and then died accidentally during convalescence, providing an unparalleled opportunity to examine the histopathology ...

PURPOSE The current live attenuated rabies vaccine must be replaced with a safer vaccine based on the ERAGS strain to prevent rabies in South Korea. We evaluated the safety and immunogenicity of a new strain in dogs and cattle. MATERIALS AND METHODS The ERAGS strain, featuring two mutations altering two amino acids in a glycoprotein of rabies virus, was propagated in NG108-15 cells. We lyophi...

Recent studies in an experimental model of rabies indicated that there are major structural changes in the brain involving neuronal processes that are associated with severe clinical disease. Cultured adult mouse dorsal root ganglion (DRG) neurons are a good in vitro model for studying the mechanisms involved in rabies virus-induced degeneration of neurites (axons) because, unlike other neurona...

The first isolation of the rabies virus in frugivorous bats of the species Artibeus lituratus in Montes Claros, State of Minas Gerais, is presented. The diagnosis was obtained through the direct immunofluorescence reaction, biological tests and viral profiling. Although canine rabies is under control in this city, the rabies virus continues to circulate in bats in the urban area.

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antig...