Plaque brachytherapy has been a mainstay of treatment for choroidal melanoma to achieve intraocular tumor control. The most common radioisotopes used for treating smaller sized tumors are Iodine-125 in North America and Ruthenium-106 in Europe. Proton beam radiotherapy is available at a few centers and may also be used to achieve local tumor control. Both plaque and proton beam therapy are know...

AIM To review the types of nonglaucomatous optic neuropathies seen in Port Harcourt, Nigeria. MATERIALS AND METHODS Medical case records of all cases of nonglaucomatous optic neuropathy seen in the Eye Clinic of University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria over a 5-year period were reviewed. Relevant data including patient demography, presenting visual acuity and intr...

PURPOSE Dominant optic atrophy (DOA) is the most common form of autosomal inherited optic neuropathy, mainly caused by mutations in the optic atrophy 1 (OPA1) gene. The purpose of this study was to detect OPA1 gene mutations and associated phenotypes in Chinese patients with suspected hereditary optic neuropathy. METHODS A cohort of 193 Chinese families with suspected hereditary optic neuropa...

CONTEXT Leber's hereditary optic neuropathy is an important cause of progressive painless visual loss among young male patients. OBJECTIVE To report on a case of a young patient with a clinical and neurophysiological condition suggestive of Leber's hereditary optic neuropathy, confirmed by genetic testing. CASE REPORT We describe a 17-year-old male with progressive bilateral visual loss. Tw...

The universal definition of glaucoma is that it is an optic neuropathy with assorted etiology, which disturbs the optic nerve head, thereby resulting in visual loss and permanent impairment of visual function [2]. On the other hand, primary open angle glaucoma is an optic neuropathy that is commonly associated with increased intraocular pressure. High intraocular pressure leads to retinal gangl...

PURPOSE The purpose of this study was to report the case of a female patient who had a giant cell tumor in the paranasal sinus during childhood, and while undergoing multiple resection surgeries experienced optic atrophy in both eyes. CASE PRESENTATION This study involved a 35-year-old woman who was previously diagnosed with a giant cell tumor of the paranasal sinus bone at age 13. A CT scan ...

Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a rando-mized, placebo-controlled trial. et al. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. Brain (this issue) 2011. Koilkonda RD, Guy J. Leber's hereditary optic neuropathy – gene therapy: from benchtop to bedside. Do idebenone and vitamin therapy shorten the time to...

First proposed by De Wecker! in 1872 as a treatment for neuroretinitis, optic nerve sheath decompression (or fenestration) is an operation that has caused much controversy. This surgical therapy was not seriously considered until Davidson" and Smith, Hoyt, and Newton" reintroduced it in 1969 as an alternative therapy for chronic disk edema. Over the next 19 years, however, only about 60 cases o...