PURPOSE To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer. METHODS Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate cancer patients diagnosed during 1995-2007 who had one or more adverse pathological features after prostatectomy. The final cohort of 6,137 eligi...

Radiation therapy is one of the most important treatment tools in cancer therapy. It has a wide variety of indications for many malignant tumors, mostly for local control, whether a curative or palliative outcome is the intent, or as preor post-operative treatment as either neoadjuvant or adjuvant therapy. Radiation therapy is commonly used along with hormone therapy or chemotherapy. The full s...

introduction relative dose computation is a necessary step in radiation treatment planning. therefore, finding an approach that is both fast and accurate seems to be necessary. the purpose of this work was to investigate the feasibility of natural cubic spline to reconstruct dose maps for linear accelerator radiation treatment fields in comparison with those of the simulation. materials and met...

The hematopoietic syndrome is anticipated when a dose of radiation greater than 100 cGy is received. The resulting clinical situation is life-threatening because of opportunistic infections and gradual decline in immune competency due to irradiation. Because of evidence of a possible immunomodulatory role for cimetidine, an antagonist of histamine H2 receptors, we studied the effects of thi...

Background: In conventional radiation therapy, regarding normal tissue tolerance, the treatment of bulk tumors is one of the remaining challenges. Grid Radiation Therapy (GRT) is a technique to deliver high doses, approximately 15 – 20 Gy per fraction, to several small volumes located in a large radiation field. This can be performed using a grid block. The current work has concentrate...