For radiobiology research on the health risks of galactic cosmic rays (GCR) ground-based accelerators have been used with mono-energetic beams of single high charge, Z and energy, E (HZE) particles. In this paper, we consider the pros and cons of a GCR reference field at a particle accelerator. At the NASA Space Radiation Laboratory (NSRL), we have proposed a GCR simulator, which implements a n...

This article provides a summary of presentations focused on critical education and training issues in radiation oncology, radiobiology and medical physics from a workshop conducted as part of the 60th Annual Meeting of the Radiation Research Society held in Las Vegas, NV (September 21-24, 2014). Also included in this synopsis are pertinent comments and concerns raised by audience members, as we...

Traditional factors of DNA damage and tumor cell kill, described by the "4 R's" of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a "5th R," (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.

Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-51451; Naval Medical Research Institute, Bethesda, Maryland 20814-50552; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2 Y23; and Department of Infectious Diseases, Instituto Nacional de la Nutricion, Salvador Lubiran, Calle Vasco de Quiroga 15, Delegacion Tlalpan...

From the *Leuhaemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB; the eMRC Radiobiology Unit, Didcot 0XI10Rs United Kingdom; the $Oncogene and Tumor Suppressor Gene Program, La Jolla Cancer Research Foundation, La Jolla, California 92037; and the IIDepartment of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine...

There are radiobiological rationales supporting hypofractionated radiotherapy for prostate cancer. The recent advancements in treatment planning and delivery allow sophisticated radiation treatments to take advantage of the differences in radiobiology of prostate cancer and the surrounding normal tissues. The preliminary results from clinical studies indicate that abbreviated fractionation prog...

The British Journal of Radiology is the official peer reviewed research journal of the British Institute of Radiology. It is a multidisciplinary journal covering all clinical and technical aspects of diagnostic imaging, radiotherapy and oncology, medical physics and radiobiology. BJR is an international journal containing papers from both the UK and overseas, and is circulated to members of the...