Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64...

INTRODUCTION The binding of radiopharmaceutical to serum proteins is thought to be an important factor that restricts its excretion and accumulation in tissue. We calculated the effect of inhibitors of serum protein binding using a hypothetical radiopharmaceutical. In vitro experiments and protein binding inhibitor-loaded monkey scintigraphy were then conducted using (123)I-N-isopropyl-p-iodoam...

Abstract Objectives Radiopharmaceuticals, since the discovery of first medical application radioactive isotope, have been essential therapeutics for diagnosis and treatment numerous diseases. Since Directive 2001/83/EC entered in force, European regulatory authorities established a harmonised framework to set quality requirements industrial production radiopharmaceuticals. However, little is kn...

in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

Background: Prostate-specific membrane antigen (PSMA) has gained high attention as a useful biomarker in the imaging evaluation of prostate cancer with positron emission tomography (PET) during recent years. [68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer. Preparation conditi...

Easily synthesised and structurally well-defined novel imaging/therapeutic radiopharmaceutical agents for bone metastases are described.

Abstract Background For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, production of radiopharmaceuticals needs to fulfil requirements good manufacturing practice. scope this work, we focused on positron emitter gallium-68 and therapeutically beta- gamma-emitter lutetium-177, as they are routinely for in-house s...

INTRODUCTION: The results of studies clinical potential a new domestic radiopharmaceutical 177 Lu-DOTA-PSMA in patients with metastatic castration-resistant prostate cancer are presented this article. OBJECTIVE: pharmacokinetics, safety and tolerability were studied. Tolerability increasing activities — 5.0, 7.5 10.0 GBq was investigated. MATERIALS AND METHODS: study included 12 cancer, who pro...

this radionuclide is almost exclusively produced from the decay of its parent 99mo. 99mtc is themost available and important nuclide used as a diagnostic agent in nuclear medicine. to develop anewly practical 99mtc generator using ( n,y ) 99mo, an inorganic polymer adsorbent has beendeveloped framed with oxygen-zirconium-chlorine bonds with a high adsorption of mo, thepolyzirconium adsorbent wa...