In this proposal, the combination of vascular normalization with HIF­1 blockade is sug­ gested as a possible means to radiosensitizing tumors. Research has shown that, after ad­ ministering antiangiogenic agents, there is window of vascular normalization in which tumor hypoxia is alleviated, and tumor radiosensitivity is increased. Recent research also shows that HIF­1 blockade after fractionat...

Tocols induce high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF mobilises progenitors that allow mice that have been severely immunocompromised by exposure to acute, high-dose ionising irradiation to recover and to survive. The neutralisation of G-CSF abrogates the radioprotective efficacy of tocols. This article reviews studies in which CD2F1 mice were irradiated with suffici...

Compounds based on cerium are highly promising objects in biotechnology regarding their high biological activities such as antiviral, antibacterial, antifungal, neuro- and radioprotective action, antioxidant activity. On basis is possible to develop compositions capable of activating the systems cellular humoral immune defence use them for prevention therapy viral diseases, which makes it achie...

Radiotherapy is one of the standard cytotoxic therapies for cancer. However, it has a profound impact on ovarian function leading to premature ovarian failure and infertility. Since none of the currently available methods for fertility preservation guarantees future fertility, the need for an effective radioprotective agent is highly intensified. The present study investigated the mechanisms of...

Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective radioprotective agent is evident. The present study investigated the mechanism of potential radioprotective effect of sodium selenite on radiation-induced ovarian failure and whether sodium selenite can stimulate in-vivo follicular development in ex...

Vojtěch Kamarád was born on August 10, 1949 in Štěpánov. He received his MD from the Faculty of Medicine, Palacký University in Olomouc in 1973. Then he took a position at the Department of Histology and Embryology where he later became associate professor (1982). In 1995 Dr. Kamarád decided to leave academia and became a product specialist for pharmaceutical company Schering-Plough. Three year...

BACKGROUND Radiation therapy plays an important role in lung carcinoma treatment. However, the incidence of symptomatic radiation-induced lung injury is high. This study aimed to evaluate radioprotective effects of flavonoids extracted from Astragalus complanatus and mechanisms of action against radiation damage. METHODS Alteration in antioxidant status and levles of several cytokines were in...

Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells.Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the s...

Although tumor gene therapy falls behind its clinical use, the combination of irradiation and gene therapy is full of promise in cancer therapy based on traditional radiotherapy, chemotherapy and surgery. We have termed it as radiogenic therapy. This review focuses on the following aspects of radiogenic therapy in recent years: improvement of gene transfer efficiency by irradiation, radiotherap...