Between a group of non sulphydryl radioprotectors (methanol, formaldehyde, acetaldehyde, formiate, acetate, ethanol and tryptophan) ; ethanol and tryptophan were selected because its high protector action on irradiated purine and pyrimidine bases. At molarities of the order of 10~4 for tryptophan-ethanol and bases and DNA the respective DRF values were: for guanine: 20.58; for adenine: 3.75; fo...

It was previously shown on heat shock protein (Hsp)-overexpressing cell lines that the increased intracellular content of Hsp70 or Hsp27 is associated with the elevated radioresistance. However, it was so far unknown whether the in vivo Hsp induction by stressful preconditioning can confer radioprotection at the tissue and cellular levels. In the present study, we examined how the in vivo up-re...

Ionising radiation (IR) is responsible for various types of tissue injury leading to morbidity at low doses and mortality at high radiation exposure. Although many radioprotective and pharmacological agents are being tested for decreasing radiation injury, however, the availability of Amifostine as the only clinically used radioprotector with limited indication has prompted us to find out new p...

Radiation therapy is one of the cornerstones of modern multidisciplinary cancer treatment. Normal tissue tolerance is critical as radiation-induced side effects may compromise organ function and quality of life. The importance of normal tissue research is reflected by the large number of scientific articles, which have been published between 2006 and 2010. The present study identified important...

Background and purpose Angiosarcoma is associated with a poor prognosis and is treated with radiotherapy. Although FGF1 is a potential radioprotector, the influence of FGF1 on the malignancy of angiosarcoma remains unknown. Materials and methods Highly stable FGF1 mutants, which exhibit stronger mitogenic activity than wild-type FGF1, were examined as strong radioprotectors and signaling agon...

The idea to hold an international conference on radiation and health arose as a natural response to the mounting evidence of serious health effects on populations resulting from the Chernobyl accident. The nature of the Chernobyl accident, where large amounts of radioactive nuclides spread in the reactor area and all over Europe, dictated the emphasis of the presented papers covering both direc...

In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at t...

Unplanned exposure to radiation can cause side effects on high-risk individuals; meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding the tumor. Besides the direct radiation damage, most of the ionizing radiation- (IR-) induced injuries were caused by generation of reactive oxygen species (ROS). Human mesenchymal stem cells (hMSCs), which possess self-renew an...