نتایج جستجو برای: radioresistant
تعداد نتایج: 1156 فیلتر نتایج به سال:
TMET-15. CYTOCHROME C OXIDASE MEDIATES CELLULAR IRON HOMEOSTASIS AND RADIORESISTANCE IN GLIOBLASTOMA
Abstract Defining the molecular mechanism(s) responsible for adaptive radioresistance in glioblastoma (GBM) is necessary development of effective treatment options. The cellular labile iron pool (LIP) very important determining response to radiation, as it contributes radiation-induced production reactive oxygen species (ROS). Recently, cytochrome c oxidase (CcO), a mitochondrial heme-containin...
Radioresistant host elements mediate positive selection of developing thymocytes, whereas bone marrow-derived cells induce clonal deletion of T cells with receptors that are strongly autoreactive. In contrast to T cell development, little is known about the elements governing the natural killer (NK) cell repertoire, which, similar to the T cell repertoire, differs between individuals bearing di...
Deinococcus wulumuqiensis R12, isolated from radiation-polluted soil, is a red-pigmented strain of the extremely radioresistant genus Deinococcus. It contains a major carotenoid, namely, deinoxanthin. Here, we present a 3.39-Mb assembly of its genome sequence, which might provide various kinds of useful information related to Deinococcus, such as about the key enzymes of its radioresistance mec...
INTRODUCTION Radioresistant brain tumor vasculature is thought to hamper the efficiency of adjuvant cancer therapies. However, little is known regarding the signalling pathways involved in the angiogenic response to brain tumor-derived growth factors in irradiated human brain microvascular endothelial cells (HBMEC). The goal of this study is to assess the effect of ionizing radiation (IR) on HB...
BACKGROUND The purpose of this study was to identify miRNAs and genes involved in nasopharyngeal carcinoma (NPC) radioresistance, and explore the underlying mechanisms in the development of radioresistance. METHODS We used microarrays to compare the differences of both miRNA and mRNA expression profiles in the radioresistant NPC CNE2-IR and radiosensitive NPC CNE2 cells, applied qRT-PCR to co...
Peritoneal exudate T lymphocytes from mice experimentally infected with the intracellular bacterium Listeria monocytogenes secreted high interleukin 2 activities after interaction with syngeneic normal macrophage presenting listerial antigen in vitro. L. monocytogenes-immune cells secreting IL 2 were radioresistant and bore the phenotype Thy 1(+) Lyt 1(+)23(-).
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