نتایج جستجو برای: rap1a
تعداد نتایج: 218 فیلتر نتایج به سال:
Death-associated protein kinase (DAPk) was recently suggested by sequence homology to be a member of the ROCO family of proteins. Here, we show that DAPk has a functional ROC (Ras of complex proteins) domain that mediates homo-oligomerization and GTP binding through a defined P-loop motif. Upon binding to GTP, the ROC domain negatively regulates the catalytic activity of DAPk and its cellular e...
The VacA cytotoxin, produced by toxigenic strains of Helicobacter pylori, induces the formation of large vacuoles highly enriched in the small GTPase rab7. To probe the role of rab7 in vacuolization, HeLa cells were transfected with a series of rab mutants and exposed to VacA. Dominant-negative mutants of rab7 effectively prevented vacuolization, whereas homologous rab5 and rab9 mutants were on...
Higher burden of PVC is associated with heart failure and cardiovascular events. Genetic background pathogenesis premature ventricular complex (PVC) remain uncertain despite recent advances in mechanisms arrhythmogenesis. To study the genetic higher comparison very low PVC. A total 1222 patients both 24-hour Holter electrocardiogram data genomic were enrolled. Patients daily (<0.1%) defined as ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید