The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing. In vertebrates, H2A.Z has two hypervariants, H2A.Z.1 and H2A.Z.2, that have almost identical sequences except for three amino acid residues. Due to such similarity, functional specificity of these hypervari...

Abstract Ordovician and Silurian siliciclastic, volcanic, plutonic rocks in the southern Appalachian eastern Blue Ridge western Inner Piedmont, formerly interpreted as components of an obducted Taconic arc terrane, are recognized parts paired arc/back-arc system that formed on seaward edge Laurentian plate. New crystallization ages from metamorphosed plutonic-volcanic intruding intercalated wit...

A study was conducted on the arc and melting efficiency of the plasma arc, gas tungsten arc, gas metal arc, and submerged arc welding processes. The results of this work are extended to develop a quantitative method for estimating weld metal dilution in a companion paper. Arc efficiency was determined as a function of current for each process using A36 steel base metal. Melting efficiency was e...

OBJECTIVE In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peripherally restricted CB1R antagonist JD5037 could be attributed to endogenous leptin due to the rapid rev...

Control of the Gas Metal Arc welding process is becoming increasingly sophisticated, due to improvements in technology and a better understanding of the process itself. To effectively conduct research in this area, it is necessary to have equipment that is extremely flexible in both architecture and operation. Experimental power sources and a welding test facility have been developed at the Uni...

Plant disease resistance is often mediated by nucleotide binding-leucine rich repeat (NLR) proteins which remain auto-inhibited until recognition of specific pathogen-derived molecules causes their activation, triggering a rapid, localized cell death called a hypersensitive response (HR). Three domains are recognized in one of the major classes of NLR proteins: a coiled-coil (CC), a nucleotide ...

Each of the eight 1.2 MW RF klystrons for the PEP-II storage rings require a 2.5 MVA DC power supply of 83 Kv at 23 amps. The design for the suply was based on three factors: low cost, small size to fit existing substation pads, and good protection against damage to the klystron including klystrong gun arcs. The supply uses a 12 pulse 12.5 KV primary thyristor “star point controller” with prima...