نتایج جستجو برای: rara positive apl
تعداد نتایج: 662831 فیلتر نتایج به سال:
background: acute promyelocytic leukemia (apl) is a subclass of acute myeloid leukemia. the chromosomal aberration in 95% of apl cases is t(15; 17) (q22; q21), which prevents cell differentiation. characterization of the underlying molecular lesion is valuable in determining optimal treatment strategy. the goal of this study was to develop a new and powerful flow- fish technique to detect the l...
A 66-year-old man with a history of hepatitis C virus and liver transplantation presented to the emergency department for shortness of breath. He had received weekly filgrastim for chronic neutropenia, and immediately before admission he had received 3 days of filgrastim and 1 day of pegfilgrastim. A hemogram showed a white blood cell count of 4.54 K/mL with 23% blastic cells. Emergent bone mar...
We have previously shown that a specific promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) DNA vaccine combined with all-trans retinoic acid (ATRA) increases the number of long term survivors with enhanced immune responses in a mouse model of acute promyelocytic leukemia (APL). This study reports the efficacy of a non-specific DNA vaccine, pVAX14Flipper (pVAX14), in both APL and hi...
The retinoic acid receptor a (RARa) and the my1 gene are involved in the translocation breakpoint t(15;17)(q22;q21) in acute promyelocytic leukemia (APL). The majority of the breakpoint sites have been mapped within the second intron of the RARa gene; however, the breakpoint sites on the my1 gene are variable. Using primer sets derived from exon 2 or exon 3 of the RARa gene and a primer derived...
BACKGROUND The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutati...
BACKGROUND The progressive shortening of telomeres and the activation of telomerase have been considered to be one of the key mechanisms in cellular immortalization and tumor progression. PATIENTS AND METHODS About 300 sequential samples were collected from 40 patients during the course of acute promyelocytic leukemia (APL) disease. Telomerase activity (TA) and terminal restriction fragment (...
PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defective PML/RARA mutants, were deficient in colo...
Acute promyelocytic leukaemia (APL) is characterised by proliferation of abnormal promyelocytes. The reciprocal translocation between the long arms of chromosomes 15 and 17, and the fusion between the retinoic acid receptor (RARa) gene, and PML gene, is unique to APL. Because of unsuccessful cytogenetic analysis of conventional G-banding technique (mitoses were not observed), we diagnosed three...
cute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with unique morphologic, cytogenetic, molecular and clinical features. Besides the classical hypergranular variant, there is also a cytological microgranular variant with significant clinical implications in both children and adults. Moreover, a basophilic form and a hyperbasophilic microgranular variant have been describe...
Distinct epidemiological characteristics have been described in Acute Promielocytic Leukemia (APL). Populations from Latin America have a higher incidence of APL and in some geographic areas a distinct distribution of the PML main differences in APL epidemilogy in Latin America as well as treatment outcomes. Introduction. Geographical variations in frequency and clinical characteristics of hema...
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