Neonatal hypoxia-ischemia (nHI) is a major cause of death or subsequent disabilities in infants. Hypoxia-ischemia causes brain lesions, which are induced by strong reduction oxygen and nutrient supply. Hypothermia the only validated beneficial intervention, but not all newborns respond to it today no pharmacological treatment exists. Among possible therapeutic agents test, trans -resveratrol an...

OBJECTIVES Dexamethasone (Dex) causes neurodegeneration in developing brain. Insulin-like growth factor-I (IGF-I) and -II (IGF-II) are potent neurotrophic and differentiation factors and play key roles in the regulation of growth and development of CNS. Current project evaluated the effects of Dex on IGF-I and -II in developing rat brains. MATERIAL AND METHODS Sprague-Dawley rat pups in each ...

Introduction: Pheromones play a great role in the reproductive and social behavior of animals. The main sources of pheromones are urine and paracrine secretions. Through the neuroendocrine system, prolactin is a safe parameter to measure and compare the effects of pheromones on the sexual, maternal and also lactating behavior. Methods: Female rats were divided into 19 groups (n=8). To measur...

objective(s): epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. gestational stress has been shown to be an important factor for affecting seizure susceptibility. the present study was conducted to address whether gestational stress may affect pentylentetrazol (ptz)-induced epileptic behavior in rat offspring in a sex- and age- dependent...

In order to investigate the postnatal recruitment process, gene expression in the brown adipose tissue of rat pups was followed during the first 20 h of life. In normal pups, the level of mRNA coding for the uncoupling protein thermogenin increased markedly but gradually within the first 24 h. Lipoprotein lipase and actin mRNA levels were relatively low and remained constant. In pups exposed to...

Varied milk delivery contingencies differentially affect sucking in rat pups as measured by jaw-muscle electromyographic activity. In Experiment I we found that 11-13-day-old pups sucked more frequently when receiving tiny intermittent pulses of milk than when receiving no milk, and continued to suck at a high rate for at least 30 min after cessation of milk delivery. In subsequent experiments ...

A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at age 4-6 months. However, this neonatal model requires optimization and a detailed study into metabolic hormonal parameters adult animals. The aim work was these male rats deprived breast milk 19-21 days, which achieved by treating lactating females with bromocriptine. Adult showed an increased b...

We hypothesize that changes in adrenal gene expression mediate the increased plasma corticosterone and steroidogenesis in rat pups exposed to hypoxia from birth. In the current study, rat pups (with their dams) were exposed to hypoxia from birth and compared with pups from normoxic dams fed ad libitum or pair fed to match the decreased maternal food intake that occurs during hypoxia. Microarray...

We investigated the effects of isolation, huddling, and air temperature on ultrasound production by rat pups. Experiment 1 showed that ultrasound production by 8- to 9-day-olds was minimal at thermoneutrality and increased in response to small deviations of air temperature on either side of the thermoneutral zone. Experiments 2 and 3 showed that suppression of ultrasound production by contact w...

To determine the degree to which the leptin receptor mutation (fa) influences the responsiveness to leptin during the first postnatal week, we injected recombinant leptin (600 pmol. g-1. day-1 sc from day 1 to day 7) into wild-type (+/+), heterozygous (+/fa), and fatty (fa/fa) rat pups. Growth and final body fat content of these leptin-treated pups were compared with those of saline-treated lit...