The fragment-based approach is now well established as an important component of modern drug discovery. A key part in establishing its position as a viable technique has been the development of a range of biophysical methodologies with sufficient sensitivity to detect the binding of very weakly binding molecules. X-ray crystallography was one of the first techniques demonstrated to be capable o...

On 28 August 2014, the crystallographic community lost one of its most energetic, influential and beloved members with the passing of Felix Frolow. He was 67 years old. All who knew him throughout the years, either in person or through communicating with him, felt the pain of the loss. Felix Frolow was educated as a physicist, completing his Bachelor and MSc studies at the Gorky State Universit...