ray repair cross complementing protein 3

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

2017

Claire Breslin Rajam S. Mani Mesfin Fanta Nicolas Hoch Michael Weinfeld Keith W. Caldecott

The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) and is important for genetic integrity and normal neurological function. One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that proces...

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XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2012

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The X-ray Repair Cross-Complementing Group 1 Arg399Gln Genetic Polymorphism and Risk of Hepatocellular Carcinoma in an Iranian Population

Journal: :Middle East Journal of Digestive Diseases 2018

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DNA Repair Gene X-Ray Repair Cross Complementing Group 1 Arg194Trp Polymorphism on the Risk of Lung Cancer: A Meta-Analysis on 22 Studies

Journal: :Journal of Thoracic Oncology 2010

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Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma

Journal: :BioMed Research International 2020

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بررسی پلی مورفیسم arg۱۹۴trp ژن xrcc۱ و خطر ابتلا به ناباروری ایدیوپاتیک مردان

ژورنال: :طب جنوب 0

سمیرا مرزبند samira marzband department of biology, faculty of sciences, university of guilan, rasht, iranگروه زیست شناسی، دانشکده علوم پایه، دانشگاه گیلان، رشت، ایران فرهاد مشایخی farhad mashayekhi department of biology, faculty of sciences, university of guilan, rasht, iranگروه زیست شناسی، دانشکده علوم پایه، دانشگاه گیلان، رشت، ایران زیور صالحی zivar salehi department of biology, faculty of sciences, university of guilan, rasht, iranگروه زیست شناسی، دانشکده علوم پایه، دانشگاه گیلان، رشت، ایران محمدهادی بهادری mohammadhadi bahadori cellular and molecular research center, faculty of medical sciences, guilan university of medical siences, rasht, iranمرکز تحقیقات سلولی و مولکولی، دانشکده علوم پزشکی، دانشگاه علوم پزشکی گیلان، رشت، ایران

زمینه: x-ray repair cross complementing group 1 (xrcc1) به عنوان یک پروتئین داربستی در ترمیم برداشت باز آلی (ber) و ترمیم شکست تک رشته dna (ssbr) عمل می کند. پلی مورفیسم های این ژن موجب تغییر در بازده ترمیم می شوند که ممکن است زمینه ابتلای افراد به بیماری های مختلف را فراهم سازد. هدف از این پژوهش بررسی ارتباط بین پلی مورفیسم xrcc1 arg194trp و ناباروری ایدوپاتیک مردان در استان گیلان میباشد. موا...

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Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.

Journal: :Molecules 2016

Junpei Yamamoto Chiaki Takahata Isao Kuraoka Kouji Hirota Shigenori Iwai

Nucleoside/nucleotide analogs that lack the 3'-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA damaging agents, and tyrosyl-DNA phosphodiesterase 1, a DNA repair enzyme, is reportedly able to remove su...

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X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Gastric Cancer Risk: A HuGE Review and Meta-Analysis

Journal: :American Journal of Epidemiology 2011

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Early decrease of XRCC1, a DNA base excision repair protein, may contribute to DNA fragmentation after transient focal cerebral ischemia in mice.

Journal: :Stroke 1999

M Fujimura Y Morita-Fujimura T Sugawara P H Chan

BACKGROUND AND PURPOSE DNA damage and the DNA repair mechanism are known to be involved in ischemia/reperfusion injury in the brain. The x-ray repair cross-complementing group 1 (XRCC1) protein plays a central role in the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase beta. The present study examined the protein expression of XRCC1 and DNA fragmentation b...

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Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003

Wei Zhou Geoffrey Liu David P Miller Sally W Thurston Li Lian Xu John C Wain Thomas J Lynch Li Su David C Christiani

XRCC1 (X-ray cross-complementing group 1) and ERCC2 (excision repair cross-complementing group 2) are two major DNA repair proteins. Polymorphisms of these two genes have been associated with altered DNA repair capacity and cancer risk. We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk. In this case...

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