The probability of faults occurring in the field increases with the evolution of the CMOS technologies. It becomes, therefore, increasingly important to analyze the potential consequences of such faults on the applications. Fault injection techniques have been used for years to validate the dependability level of circuits and systems, and approaches have been proposed to analyze very early in t...

PURPOSE To determine the effect of ranibizumab on visual acuity (VA) following a 3-year treatment period for patients diagnosed with wet age-related macular degeneration. To establish whether baseline VA and injection frequency influence visual outcomes. PATIENTS AND METHODS Retrospective review of 70 patients (76 eyes) treated with 0.5 mg intravitreal ranibizumab for 3 consecutive months, an...

Operating time for idiopathic hydroceles and epididymal cysts is scarce as these conditions compete with an increasing caseload of more consequential surgical disease. Therapy is often relegated to repeated aspiration. Sclerotherapy appears to be effective in a majority of published trials, but comparative effectiveness, efficacy and safety of most agents, including phenol versus tetracycline, ...

An important decision in the development of a mixed oil and natural gas field is whether to produce or re-inject the natural gas. There is a trade-off between the income from the sale of natural gas and the higher oil production obtained from re-injection. We consider the optimal timing problem of when to stop natural gas injection for a set of offshore petroleum fields using a real options app...

Attaching the phosphonated molecular catalyst [ReIBr(bpy)(CO)3]0 to the wide-bandgap semiconductor TiO2 strongly enhances the rate of visible-light-driven reduction of CO2 to CO in dimethylformamide with triethanolamine (TEOA) as sacrificial electron donor. Herein, we show by transient mid-IR spectroscopy that the mechanism of catalyst photoreduction is initiated by ultrafast electron injection...

Indomethacin has been used to treat patent ductus arteriosus (PDA). Re-opening of the ductus arteriosus (DA) after indomethacin therapy, however, is common, although the reason is unclear. Patency of the ductus arteriosus is thought to be maintained primarily by the vasodilatory effect of PGE2 in fetuses and neonates. The enzyme, 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes the in...

We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO ...

The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-mediated synaptic silencing include very long duration, high potency and localized action. However, there is a fear of possible side-effects of BoNT...

Abstract Fault reactivation and associated microseismicity pose a potential threat to industrial processes involving fluid injection into the subsurface. In this research, fracture criticality, defined as gradient of critical pressure change trigger seismicity (Δ p c / h ), is proposed novel reservoir depth-independent metric fault slip susceptibility. Based on statistics probabilistic evaluati...

Considering the global drive toward net-zero carbon emissions in near future, need to find clean sources of energy has never been more important. It is estimated that globally there are tens thousands depleted and abandoned oil fields may be adapted produce green energy. These re-cycled with help air injection, either from production hydrogen, as a direct result oxidation oil, or exploitation i...