نتایج جستجو برای: receptor targeting
تعداد نتایج: 717575 فیلتر نتایج به سال:
The blood-brain barrier (BBB) is a major obstacle to treating several brain disorders. Focused ultrasound (FUS) in combination with intravascular microbubbles increases BBB permeability by opening tight junctions, creating endothelial cell openings, improving endocytosis and increasing transcytosis. Here we investigated whether combining FUS transferrin receptor-targeting liposomes would result...
Circulating tumor cells (CTCs) play a pivotal role in the early diagnosis of pheochromocytoma (PCC). Herein, we fabricated new dual-targeting nanoprobe for coinstantaneous identification rare PCC-CTCs from peripheral blood via targeting norepinephrine transporter (NET) and somatostatin receptor SSTR2 overexpressed on surface PCC cells. Meta-iodobenzylguanidine (MIBG) functionalized magnetic Fe3...
Targeting the human epidermal growth factor receptor-2 (HER2) is cornerstone of treatment HER2+ breast cancer patients. The mechanism action trastuzumab partly based on lysis tumor cells via antibody dependent cellular cytotoxicity (ADCC), which among others involves NK cells. However, cell and CD8+ T-cell activity inhibited by binding inhibitory receptor NKG2A to HLA-E. HLA-E expression upregu...
Newly synthesized Arc mRNA is selectively targeted to synapses that have experienced particular patterns of activity. Here, we demonstrate that the targeting requires NMDA receptor activation. Arc expression was induced by an electroconvulsive seizure, and the newly synthesized mRNA was then targeted to synaptic sites by activating the perforant path projections to the dentate gyrus. When micro...
Recent advances in basic and translational research have elucidated important molecular alterations that underlie neoplastic transformation and progression in non-small cell lung cancer (NSCLC). Specifically, the epidermal growth factor receptor (EGFR) signal transduction pathway presents therapeutic opportunities at various levels from the extracellular ligands to the transmembrane receptor an...
A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the receptor and/or inducing its degradation. We have developed recombinant antibodies targeting human TfR1 (ch128.1 and ch128.1Av), which induce receptor degradation and are cytotox...
Impairment of health after overcoming the acute phase COVID-19 is being observed more and frequently. Here different symptoms neurological and/or cardiological origin have been reported. With symptoms, which are very similar to ones reported but not caused by SARS-CoV-2, occurrence functionally active autoantibodies (fAABs) targeting G-protein coupled receptors (GPCR-fAABs) has discussed be inv...
Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy. Recently, we have developed a targeting method for LVs by incorporating engineered measles virus (MV) glycoproteins, the hemagglutinin (H), responsible for recep...
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