Ikaros, Notch, and GATA1 cross paths during megakaryopoiesis ----------------------------------------------------------------------------------------------------Ivan Maillard UNIVERSITY OF MICHIGAN In this issue of Blood, Malinge et al describe new reciprocal interactions between Ikaros, Notch, and GATA transcription factors during megakaryocyte development. Ikaros represses megakaryocytic gene...

A detailed structured backward error analysis for four kinds of Palindromic Polynomial Eigenvalue Problems (PPEP) ( d ∑ l=0 Alλ l ) x = 0, Ad−l = εA ⋆ l for l = 0, 1, . . . , ⌊d/2⌋, where ⋆ is one of the two actions: transpose and conjugate transpose, and ε ∈ {±1}. Each of them has its application background with the case ⋆ taking transpose and ε = 1 attracting a great deal of attention lately ...

Many applications give rise to structured, in particular T-palindromic, matrix polynomials. In order to solve a polynomial eigenvalue problem P (λ)x = 0, where P (λ) is a T-palindromic matrix polynomial, it is convenient to use palindromic linearizations to ensure that the symmetries in the eigenvalues, elementary divisors, and minimal indices of P (λ) due to the palindromicity are preserved. I...

The interest in self-reciprocal polynomials in coding theory originated with Massey (1963, 1964), who has shown tha t whenever a self-reciprocal polynomial is used as a convolutional code-generating polynomial, the resulting code may be decoded backward us well as forward, with the same hardware and the same probabil i ty of decoding error. Let G( D ) = go 4glD 4g~D ~ 4" . . 4g , D ' , where n ...

Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical and two-dimensional dual-energy X-ray absorptiometry (DXA) phenotypes in reciprocal F2 crosses between diabetic GK and normo-glycemic F344 rat str...

Several models of myopia predict that growth of axial length is stimulated by blur. Accommodative lag has been suggested as an important source of blur in the development of myopia and this study has modeled how cross-link interactions between accommodation and convergence might interact with uncorrected distance heterophoria and refractive error to influence accommodative lag. Accommodative la...

Reciprocal crosses between species can yield hybrids with different viabilities. The high frequency of this asymmetric hybrid viability ("Darwin's corollary") places it alongside Haldane's rule and the "large-X effect" as a general feature of postmating reproductive isolation. Recent theory suggests that reciprocal cross asymmetries can arise from stochastic substitutions in uniparentally inher...

The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these predictions, we need ways to quantitatively assess actual cross-reactivity between two allergens. Three parameters are mentioned: 1) the fraction of the epitopes that is cross-reactive; 2...