Recurrent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin infections are an increasingly common problem. However, there are no data on the efficacy of decolonization regimens. We prospectively evaluated 31 patients with recurrent CA-MRSA skin infections who received nasal mupirocin, topical hexachlorophene body wash, and an oral anti-MRSA antibiotic. The mean num...

Unlike IgA and IgM, IgG has not yet been shown to form covalent polymers. However in the presence of specific Ag, murine IgG3 has been shown to polymerize through noncovalent interactions. In contrast to the noncovalent oligomers found with murine IgG3, we have detected covalent dimers in three different recombinant human IgG2 Abs produced in myeloma cells. Both IgG2,kappa and IgG2,lambda can f...

Background: This study estimated the prevalence, recurrence, and predisposing factors of self-reported urinary tract infections (UTIs) and genital infections among adults with and without type 2 diabetes mellitus (T2DM). Methods: In the US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) 2008 survey, respondents reported how many times in the pa...

chronic granulomatous disease (cgd) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. we report a 2.5-year-old iranian female with multiple liver abscesses. she was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventional...

The bovine IgG1 and IgG2 isotypes exhibit large differences in effector functions. To examine the structural basis for this, the 12-domain structures of IgG1 and IgG2 were investigated by pulsed neutron scattering using a recently developed camera LOQ. This method reports on the average relative disposition in solution of the Fab and Fc fragments in IgG. The radii of gyration (RG) were found to...

Fourteen dogs naturally infected with Leishmania infantum and treated with allopurinol were monitored clinically and serologically with immunofluorescent antibody test (IFAT, amastigotes and promastigotes), enzyme linked-immunosorbent-assay (ELISA, IgG1 and IgG2) and Western blotting (WB). In all dogs therapy lead to clinical improvement together with decreasing specific antibodies in IFAT, ELI...

It has been shown that nosocomial infections or hospital acquired infections are recurrent problems, identified chiefly in intensive care facilities, surgical, and medical wards. In Trinidad and Tobago information on nosocomial infections are lacking. Within the period 1992-1995, 7,158 nosocomial infections were documented from 72,532 patients (10.0/100 admissions). In Europe, incidences vary f...

leukocyte adhesion deficiency type 1 (lad 1) is an autosomal recessive hereditary disorder resulting from deficiency of cd18, characterized by recurrent bacterial infections. we report two consanguineous patients with leukocyte adhesion deficiency type 1( lad1). these two infant boy patients were referred to us, within a short period of time, with the complaints of recurrent infections at the a...