PURPOSE In this Argentinean retrospective, collaborative, multicenter study, we examine the efficacy and tolerability of the ketogenic diet (KD) for different epilepsy syndromes. MATERIALS AND METHODS we evaluated the clinical records of 216 patients started on the KD between March 1, 1990 and December 31, 2010. RESULTS One hundred forty of the initial patients (65%) remained on the diet at...

Efstathia Tzatha, MD Steven C. Karceski, MD In the last 18 years, 12 new antiseizure medications have been discovered. Although there are more medications, there have been no medicines that are clearly better than the older ones. To be clear, the newer medicines do not seem to be any more effective at stopping seizures than the older ones. Studies have shown that about one-third of people with ...

Corpus callosum is the major interspheric fiber bundle that connects two cerebral hemispheres. agenesis among most common brain malformation, which has a wide spectrum of presentation ranging from mild intellectual disability to severe developmental delay and refractory seizures. We here report case complete corpus presenting with gait abnormality in an otherwise normal child.

objective neuropsychological impairment is an important co-morbidity of chronic epilepsy. the aim of this study was to determine the state of the cognitive and motor development of patients with refractory epilepsy. materials & methods  we studied 150 consecutive children with epilepsy who were referred to mofid children hospital, a third level public referral university hospital in tehran, ira...

BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of melatonin on seizure...

OBJECTIVES Refractory epilepsies (RE), as well as, the surgically correctable syndromes, are of great interest, since they affect the very young population of children and adolescents. The early diagnosis and treatment are very important in preventing the psychosocial disability. Therefore MRI and EEG are highly sensitive methods in the diagnosis and localization of epileptogenic focus, but als...

how to cite this article: fallah r, yadegari y, salmani nodushan m. efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital. iran. j. child. neurol 2012;6(2):39-44.   objective status epilepticus (se) is the most common pediatric neurologic emergency with high mortality and morbidity. there is no consensus on the drug of choic...

PURPOSE The aim of this study was to examine interictal, pre-ictal and ictal autonomic system disturbance by comparing heart rate variability in children with uncontrolled epilepsy with that seen in healthy controls and children with controlled epilepsy. METHODS Our study group included 20 children with refractory epilepsy, our control groups were composed of 20 children with well-controlled ...

De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seizures (FSs), refractory afebrile epilepsy, cognitive and behavioral deficits, and a 15-20% mortality rate. SCN1A mutations also lead to genetic epil...