Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads c...

   Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads c...

The delayed release and mucoadhesive properties of Cedrela gum and hydroxypropylmethylcellulose blend in diclofenac sodium tablet formulations were evaluated. Tablets were prepared by direct compression and the crushing strength and detachment force were found to increase from 74.49 ± 1.22 to 147.25 ± 2.57 N and 0.302 ± 0.36 to 1.141 ± 0.05 N from low to high level of polymers, respectively. Th...

vitamin e (α-tocopherol) is a natural antioxidant very useful for preventing the harmful effects of uv sun rays as skin aging and cancers. in this study, different mlv formulations were made using egg lecithin and varying molar ratios of α-tocopherol and/or cholesterol, and their encapsulation efficiencies were determined. the best liposomal product was incorporated into a carbomer 980 gel. the...

Penelitian ini bertujuan untuk mengetahui hasil pelepasan kadar nitrogen pada sampel pupuk dengan variasi perbandingan volume zeolit massa surfaktan kationik serta karakterisasi kimia FTIR. Pada penelitian digunakan alam dan heksadesiltrimetilammonium (HDTMA) sebagai bahan utama. Pembuatan dalam cara aktivasi menggunakan HCl 1M lalu di tambahkan HDTMA 0.05M 1:1, 1:3, 1:5, kemudian ditambahakan ...

In developing cerebellar molecular layer interneurons (MLIs), NMDA increases spontaneous GABA release. This effect had been attributed to either direct activation of presynaptic NMDA receptors (preNMDARs) or an indirect pathway involving activation of somato-dendritic NMDARs followed by passive spread of somatic depolarization along the axon and activation of axonal voltage dependent Ca(2+) cha...

Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or pH. The objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer...