OBJECTIVE(S) High blood glucose induces molecular, cellular, morphological and behavioral changes in the brain. Metabolic disturbances, contribute to the hippocampus injury and development of partial focal seizures. The aim of this study was to investigate the effects of infantile repeated hyperglycemia on neuronal density of hippocampal CA3 region in newborn Wistar male rats and its effect on ...

Effects of repeated postnatal administration of caffeine (10 and 20mg/kg s.c. daily from P7 to P11) were studied in two models of epileptic seizures characterized by spike-and-wave EEG rhythm in 18- and 25-day-old rats. Rhythmic metrazol activity (RMA, model of human absences) was induced by low dose of pentylenetetrazol (PTZ, 20mg/kg or 40mg/kg, i.p.) and minimal clonic seizures (model of huma...

Epilepsy causes repeated seizures in an individual's life, which transient irregularities the brain's electrical activity. It results different physical symptoms that are abnormal. Various antiepileptic drugs fail to minimize patient seizures. The electroencephalogram (EEG) signal recordings provide us with time-series data set for epileptic seizure detection and analysis. These signals highly ...

Severe pallid breath-holding spells (BHSs) are based on parasympathetic hyperactivity, leading to cardiac asystole, pallor, brain ischemia, loss of consciousness, and reflex anoxic seizures. In recent years, an increasing number of patients with severe pallid BHSs have been successfully treated with pacemaker implantation. We present the case of a 13-month-old girl suffering from repeated sever...

PURPOSE Aprosody and amusia are disorders commonly associated with right hemisphere abnormalities. They are regarded as negative phenomena and usually seen after strokes. We report a case of a patient who had both expressive aprosody and amusia as a clinical manifestation of right temporooccipital seizures. METHODS A 43-year-old woman had a 1-month history of monotonic speech and difficulty s...

The aim of this study is to disclose the mechanisms underlying the recruitment of neocortical networks during slow-wave sleep oscillations evolving into spike-wave (SW) seizures. 1) We investigated the activation of SW seizures in a seizure-prone neocortex by means of electrical stimuli applied within the frequency range of spontaneous sleep oscillations. Stimuli were grouped in bursts of 10 Hz...

The claustrum has been implicated in the kindling of generalized seizures from limbic sites. We examined the susceptibility of the anterior claustrum itself to kindling and correlated this with an anatomical investigation of its afferent and efferent connections. Electrical stimulation of the anterior claustrum resulted in a pattern of rapid kindling with two distinct phases. Early kindling inv...

 It has been reported that fractures are more common in epileptic patients relative to the general population. Seizures by repeated muscular contractions can increase fracture risk throughout the skeleton, but the reported papers about non traumatic vertebral fractures following a single episode of seizure are rare and mostly located in thoracic spine with only one or two vertebral fr...

Case presentation: Term newborn, appropriate for gestational age, female, normal neonatal screenings, vaginal birth, Apgar ⅞. Diagnosed with congenital syphilis, pulmonary hypertension, convulsive syndrome and altered thyroid-stimulating hormone by maternal levothyroxine use during pregnancy. At maternity, infant presented frequent seizures, receiving levetiracetam phenobarbital, in addition to...

Abstract Epilepsy is a neurological disease that affects approximately 1% of the world’s population. characterized by occurrence repeated epileptic seizures due to abnormal neuronal activity. Although this disorder currently incurable, it can be controlled for years with appropriate therapy and patient adherence. Inflammation an organism’s natural response pathological stimulus, aimed at elimin...