Objective To investigate the protective effects of epigallocatechin-3-gallate (EGCG), a major polyphenol source in green tea, against hepatic ischaemia-reperfusion injury in mice. Methods The partial hepatic ischaemia-reperfusion injury model was created by employing the hanging-weight method in C57BL/6 male mice. EGCG (50 mg/kg) was administered via an intraperitoneal injection 45 min before p...

Reperfusion therapy decreases myocardium damage during an acute coronary event and consequently mortality. However, there are unmet needs in the treatment of acute myocardial infarction, consequently mortality and heart failure continue to occur in about 10% and 20% of cases, respectively. Different strategies could improve reperfusion. These strategies, like generation of warning sign recognit...

Purpose: To evaluate the role and mechanism of action sevoflurane in liver ischemia reperfusion injury.Methods: Rats were pretreated with then underwent followed by to establish an animal model injury. Pathological changes tissues investigated hematoxylin eosin (H & E) staining, serum levels alanine aminotransferase (ALT) aspartate (AST) determined using a chemistryanalyzer. ELISA was used ...

Ischemic heart disease is a clinical syndrome resulting from myocardial ischemia and is characterized by an imbalance between the supply and demand of myocardial blood flow and myocardial oxygen metabolism. It is currently one of the major diseases that endanger human health. Early and effective reconstruction of ischemic myocardial blood perfusion is the fundamental measure taken to prevent th...

Background: The aim was to investigate the antioxidant effects of lycopene and caffeine in rats exposed renal ischemia/reperfusion injury. Materials Methods: Following right nephrectomy, 60 minutes ischemia followed by reperfusion were performed 200-250 gram Wistar albino used study. 30 before ischemia, (5 mg/kg), (50 mg/kg) + administered intraperitoneally rats. After experiment, 4 ml blood le...

Zou, Lei, Bashir Attuwaybi, and Bruce C. Kone. Effects of NKB inhibition on mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 284: G713–G721, 2003. First published December 4, 2002; 10.1152/ ajpgi.00431.2002.—Mesenteric ischemia-reperfusion injury is a serious complication of shock. Because activation of nuclear factorB (NFB) has been implicated in this process, we...

Murine reperfusion injury follows binding of specific IgM natural antibodies to neo-antigens exposed in ischemic tissue. Peptides that mimic the site of antibody binding in the injury prevent IgM binding when administered intravenously before reperfusion. To determine whether this pathogenic sequence is restricted to mice, we have tested the ability of the peptide to prevent reperfusion injury ...

BACKGROUND In patients with acute myocardial infarction, restoration of coronary flow by primary coronary intervention (PCI) can lead to profound ischaemia-reperfusion injury with detrimental effects on myocardial salvage. Non-invasive assessment of interstitial myocardial haemorrhage by T2* cardiac MRI (T2*-CMR) provides a novel and specific biomarker of severe reperfusion injury which may be ...

In clinical therapy of evolving acute myocardial infarction, coronary reperfusion has proven to be the only way to limit infarct size, provided it occurs soon enough after coronary artery occlusion. However, there is also evidence that reperfusion is accompanied by detrimental manifestations known as ‘reperfusion injury’. Reperfusion injury refers to a causal event associated with reperfusion t...

Inhalation of hydrogen gas has been proved to be an effective treatment for ischemia-reperfusion injury. There has been considerable evidence of hydrogen's protective effect to diseases related to oxidative injury, such as the ischemia-reperfusion injury of the brain, liver and heart. Our previous studies demonstrated that intraperitoneal injection of hydrogen-rich saline protected hypoxic-isch...