نتایج جستجو برای: resequencing
تعداد نتایج: 2156 فیلتر نتایج به سال:
MOTIVATION Genome resequencing and short read mapping are two of the primary tools of genomics and are used for many important applications. The current state-of-the-art in mapping uses the quality values and mapping quality scores to evaluate the reliability of the mapping. These attributes, however, are assigned to individual reads and do not directly measure the problematic repeats across th...
High-density array-based genome-wide association studies (GWAS) are complemented by exome sequencing and whole-genome resequencing-based association studies. Here we present a composite resequencing-based genome-wide association study (CR-GWAS) strategy that systematically exploits collective biological information and analytical tools for a robust analysis. We showcased the utility of this str...
Studies of queuing models with resequencing of jobs to keep the order at the output in the order of arrival are reviewed. A focus on recent authors results regarding optimal jobs assignment to heterogeneous servers is presented.
Isolating and sequencing specific regions in a genome is a cornerstone of molecular biology. This has been facilitated by computationally encoding the thermodynamics of DNA hybridization for automated design of hybridization and priming oligonucleotides. However, the repetitive composition of genomes challenges the identification of target-specific oligonucleotides, which limits genetics and ge...
DNA resequencing arrays enable rapid acquisition of high-quality sequence data. This technology represents a promising platform for rapid high-resolution genotyping of microorganisms. Traditional array-based resequencing methods have relied on the use of specific PCR-amplified fragments from the query samples as hybridization targets. While this specificity in the target DNA population reduces ...
Mixed model production lines consider more than one model being processed on the same production line in an arbitrary sequence. Nevertheless, the majority of publications in this area are limited to solutions which determine the job sequence before the jobs enter the line and maintains it without interchanging jobs until the end of the production line, which is known as permutation fl owshop. T...
Polydactyly, a common heritable limb malformation in vertebrates, is characterized by supernumerary digits. In chickens, basic characteristics and rough dominant genes have been explored in past decades; however, the elaborate pattern of inheritance and the determinant gene remain obscure. In this study, different types of polydactylism were classified by the numbers and the shapes of toes, inc...
Several recent studies have proposed methods to accelerate the receipt of a file by downloading its parts from different servers in parallel. The schemes suggested in most proposed parallel download approaches focus on reducing the total download duration. For streaming applications a more crucial performance issue is the regularity of flow of data to the application. Burstiness in data arrival...
Whole exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies
Rare single-gene disorders cause chronic disease. However, half of the 6000 recessive single gene causes of disease are still unknown. Because recessive disease genes can illuminate, at least in part, disease pathomechanism, their identification offers direct opportunities for improved clinical management and potentially treatment. Rare diseases comprise the majority of chronic kidney disease (...
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