Reserpine, on systemic administration (1) as well as after intracerebroventricular injection (2), exerts parasympathomimetic effects such as miosis, salivation, and diarrhoea. These effects have been attributed to increased central parasympathetic activity since reserpine increases the acetylcholine contents of the hy pothalamus (3). A direct parasympathomimetic action of reserpine has been exc...

Exposure of bovine chromaffin cells in primary culture to 5 microM reserpine or 25 microM forskolin results in an increase in enkephalin peptide levels within 24-48 hr; 25 microM forskolin (or cholera toxin at 50 micrograms/ml) causes a 1.5- to 2-fold increase in enkephalin peptide levels, which is maximal after 48 hr of exposure and is totally blocked by addition of cycloheximide (0.5 microgra...

Rauwolfia species (Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids (MIAs) such as reserpine, ajmalicine, ajmaline, serpentine and yohimbine. Reserpine, ajmalicine and ajmaline are powerful antihypertensive, tranquilizing agents used in hypertension. Yohimbine is an aphrodisiac used in dietary supplements. As there is no report on t...

intraperitoneal (ip) injection of bupropion (3,6, amine (4,16 mg kg•&apos;) induced dose-dependent climbing in mice. the climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist sch 233<)0 or the 0-2 antagonist sulpiride. the α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adre...

The species of the genus Rauvolfia are a reservoir indole alkaloids with proven pharmacological properties. A chloroform extract root bark vomitoria (Apocynaceae) was studied. phytochemical investigation said allowed isolated four indolic alkaloids, three which known (Reserpine, ajmaline and mauiensine) unknown phyto-constituent (3). In addition, methyl esters 3, 4, 5-trimethoxybenzoic acid (Ph...

Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachyc...

Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance...

ba ckground: legionella pneumophila is  a  dangerous pathogenic bacterium can cause serious infectious diseases especially in hospitalized immuno-compromised patients. this bacterium is shown to be resistant against different antibiotics. resistance against a wide range of antibiotics is usually mediated by efflux pump in bacteria. efflux pumps are proteinaceous transporters localized in the cy...

Hitherto behavioural investigations with reserpine have been confined to the use of very small doses, doses which weight for weight are considerably lower than those used in clinical work. Sidman (1956) used a Skinner lever pressing apparatus for investigating the effect of up to 0 1 mg./kg. reserpine on work under different reinforcement programmes. Smith, Wagman, Wagman and Riopelle (1956), i...