Ecologic niche modeling may improve our understanding of epidemiologically relevant vector and parasite-reservoir distributions. We used this tool to identify host relationships of Triatoma species implicated in transmission of Chagas disease. Associations have been documented between the protracta complex (Triatoma: Triatominae: Reduviidae) with packrat species (Neotoma spp.), providing an exc...

The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in ...

Among many cellular transcriptional regulators, Bcl11b/CTIP2 and HGMA1 have been described to control the establishment and the persistence of HIV-1 latency in microglial cells, the main viral reservoir in the brain. In this present work, we identify and characterize a transcription factor i.e. HIC1, which physically interacts with both Bcl11b/CTIP2 and HMGA1 to co-regulate specific subsets of ...

We present recent results on the modeling and numerical simulation of reservoir stimulation in Hot Dry Rocks. Our approach is based on a mechanistically faithful yet mathematically sound model, generalizing Griffith's idea of competition between bulk and surface energies. At each time increment, the fracture and displacement configuration of a reservoir is sought as the minimizer of a global en...

We examine the transverse and longitudinal components of the drag force upon a vortex filament due to the scattering of liquid 4He excitations. For this purpose, we consider a recently proposed Hamiltonian that describes the dissipative motion of a vortex, giving an explicit expression for the vortexquasiparticle interaction. The involved dissipative coefficients are obtained in terms of the re...

The dam-reservoir system is divided into the near field modeled by the finite element method, and the far field modeled by the excellent high-order doubly asymptotic open boundary DAOB . Direct and partitioned coupled methods are developed for the analysis of dam-reservoir system. In the direct coupled method, a symmetric monolithic governing equation is formulated by incorporating the DAOB wit...

Persistence of latent, replication-competent Human Immunodeficiency Virus type 1 (HIV-1) provirus is the main impediment towards a cure for HIV/AIDS (Acquired Immune Deficiency Syndrome). Therefore, different therapeutic strategies to eliminate the viral reservoirs are currently being explored. We here propose a novel strategy to reduce the replicating HIV reservoir during primary HIV infection...